The Complete byMae FAQ: Your Comprehensive Guide to Immunity Training & Family Wellness

Compare byMae Multi+ for Adults to Competitors

Compare byMae Multi+ for Littles to Competitors

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Immunity Training

Immunity Training - Core Concepts

Immunity Training - Mechanisms of Action

Immunity Training – Science & Research

Immunity Training – byMae’s Role

Immunity Training – ABB C1® by AB Biotek

Immunity Training – Practical Applications

Quality, Trust & Safety

Ingredients

Compare byMae Multi+ for Adults to Competitors

Capsules and Drink

byMae vs Ritual

Q: How does byMae multi+ for adults compare to Ritual’s Essential Multivitamin?

A: Comprehensiveness: byMae multi+ for adults offers a far more comprehensive formula than Ritual’s Essential Multivitamin. Ritual follows a “less is more” philosophy with only 9 core nutrients in its women’s multivitamin, deliberately omitting several vitamins and minerals (like calcium, vitamin C, etc.) that they assume you get from diet [1]. It does include a modest 30 mg of magnesium, which supports basic maintenance but falls short of meeting most adults’ daily needs (~310–420 mg/day) [2][3].

In contrast, byMae multi+ provides 24 essential vitamins and minerals plus a patented ABB C1® immunity training complex [4], giving it broader coverage. For example, byMae includes the full spectrum of B-complex vitamins in their bioactive forms, chelated minerals (like Ferrochel® iron), and 50 mg of magnesium bisglycinate — a more absorbable form than typically used. It also uniquely features ABB C1®, a beta-glucan, zinc, and selenium blend shown to stimulate trained immunity [5][6].

Ritual’s minimalist approach, while transparent and targeted, may leave nutritional gaps. byMae’s all-in-one strategy casts a wider net — ideal for modern lifestyles where stress, diet, and exposure demand more.

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[2] https://ritual.com/ingredients/magnesium

[3] https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

[4] https://bymae.com/products/multi-plus-drink-mix

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314659/

[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589110/

Q: I currently take Ritual. Does byMae multi+ replace it, or should I take them together?

A: Use only one multivitamin: byMae multi+ completely replaces Ritual’s multivitamin – you should not take both together. byMae’s formula already includes all the nutrients found in Ritual (like D3, B12, folate, iron, etc.) plus additional ones (such as magnesium, zinc, vitamin A, etc.) and the ABB C1® immune complex that Ritual lacks.

Taking both multivitamins concurrently would be unnecessary and could even be risky, as you’d be doubling up on certain vitamins and minerals. High doses of some nutrients can exceed safe limits and potentially cause side effects [5]. For example, Ritual provides 50 mcg of vitamin D3 and byMae has 37.5 mcg – together that’s 87.5 mcg (3,500 IU), approaching the tolerable upper intake level of 100 mcg (4,000 IU) [6]. Similarly, both contain active folate; together they could exceed the 1,000 mcg/day UL for folic acid equivalents [7].

Since byMae covers everything Ritual does — and more — you can confidently use it as a full replacement.

References:

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593442/

[6] https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/

[7] https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/

Q: Which is a better value for my money, byMae multi+ or Ritual?

A: Value and cost: byMae multi+ offers better value for your money by combining a multivitamin, immune support, and gut health support in one product. A monthly subscription of byMae multi+ is about $38 and delivers broad nutrition plus the ABB C1® immune-training complex and a prebiotic fiber base in the drink mix format [2].

By comparison, Ritual’s Essential Multivitamin costs around $33 per month [1], but lacks support for immunity or digestive health. To match byMae’s breadth of benefits, you’d need to stack additional Ritual products — like Synbiotic+ for gut health at $54/month [8] and possibly a separate immune product — which drives the monthly cost well over $80.

With byMae, you pay one price for all-in-one coverage , making it more cost-efficient and easier to manage than juggling multiple supplements.

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[2] https://bymae.com/products/multi-plus-drink-mix

[8] https://ritual.com/products/synbiotic-plus

Q: Ritual has a ‘less is more’ approach with only 9 ingredients. Why does byMae include more? Explain the benefits of a comprehensive formula.

A: Broad-spectrum benefits: Ritual’s minimalist philosophy centers around the idea that most people get sufficient nutrition from food, so they aim to “fill gaps” with just 9 ingredients [1]. This may appeal to those looking for simplicity, but it also assumes a nutritionally perfect diet — which few people consistently achieve.

byMae takes a more comprehensive approach , providing 24 essential nutrients that cover a wider range of common deficiencies. Research supports the idea that multivitamins with 10 or more nutrients are more effective at improving health outcomes, particularly in people with less-than-optimal diets [9].

Importantly, byMae’s formula includes ABB C1® , a clinically studied complex of β-glucans, zinc, and selenium that supports immune system “training” — a benefit Ritual does not offer [3]. This adds a layer of proactive health defense that minimalist formulas miss.

In short, byMae’s “more is more (when done right)” philosophy offers broader support , especially in today’s modern world of stress, nutrient-depleted food, and higher health demands.

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314659/

[9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823510/

Q: How does the Vitamin D3 in byMae compare to the Vitamin D3 in Ritual?

A: Vitamin D₃ dose and synergy: Both byMae and Ritual use vitamin D₃ (cholecalciferol) – the most bioavailable form of vitamin D. Ritual’s Essential for Women provides 50 mcg (2,000 IU) per day [1], while byMae multi+ contains 37.5 mcg (1,500 IU) [2].

Though Ritual’s dose is slightly higher, byMae’s is still generous — nearly 190% of the Daily Value — and calibrated to work synergistically with 90 mcg of vitamin K₂ (as MK-7) [2]. This pairing is intentional: vitamin K₂ helps direct calcium into the bones and away from soft tissues, reducing the risk of arterial calcification. Clinical research supports this D3+K2 synergy for optimal calcium metabolism and cardiovascular health [10].

In short, byMae may offer a more strategic formulation by focusing on effective nutrient pairing , not just higher single-ingredient numbers.

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[2] h ttps://bymae.com/products/multi-plus-drink-mix

[10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230272/

Q: How does the B12 in byMae compare to the B12 in Ritual?

A: Form and dose advantage: Both byMae and Ritual use methylcobalamin , the bioactive form of B12 that bypasses the liver’s need to convert it from synthetic forms [1][2]. However, byMae includes 14 mcg , providing 583% of the RDA , while Ritual includes 8 mcg (333% RDA) in their Essential for Women 18+ [1].

This higher dose in byMae can be especially beneficial for people with absorption issues, which become more common with age or digestive disorders. Studies show that only a small percentage of oral B12 is passively absorbed, so higher dosing helps ensure sufficiency — particularly in older adults [11].

Both formulas use the superior form of B12, but byMae provides more robust coverage , especially for those who may need a higher intake.

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[2] https://bymae.com/products/multi-plus-drink-mix

[11] h ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066334/

Q: How does the Folate in byMae compare to the Folate in Ritual?

A: MTHFR-friendly folate for everyone: Both byMae and Ritual use L-5-methyltetrahydrofolate (5-MTHF) , the active form of folate. This is important because nearly 40% of people have a common genetic variation (MTHFR) that reduces their ability to convert folic acid into usable folate [12].

byMae provides 600 mcg DFE of folate — the recommended amount for pregnancy planning and general wellness [2]. Ritual typically provides a lower dose (~200 mcg DFE) in its Essentials line [1].

By using 5-MTHF, both brands avoid synthetic folic acid, which can build up unmetabolized in the bloodstream for those with MTHFR polymorphisms. But byMae’s higher dose provides greater assurance of sufficiency, especially for women of childbearing age or those at risk for folate insufficiency.

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[2] https://bymae.com/products/multi-plus-drink-mix

[12] h ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250974/

Q: How does the Iron in byMae compare to the Iron in Ritual?

A: Iron dosage designed for women: byMae multi+ provides 13.5 mg of iron as Ferrochel® ferrous bisglycinate chelate [2], while Ritual contains 8 mg of ferrous bisglycinate [1].

Both use a gentle, stomach-friendly chelated form that is well tolerated and absorbed. But byMae’s higher dose is better aligned with the needs of menstruating women , who lose iron monthly and are more prone to deficiency. Ritual’s dose is adequate for maintenance but may fall short in women with higher demands.

Research supports bisglycinate as superior to traditional forms like ferrous sulfate — it’s less likely to cause gastrointestinal distress and more efficiently absorbed [13]. In essence, byMae offers a higher dose in the same gentle form , making it more effective for prevention and repletion.

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[2] https://bymae.com/products/multi-plus-drink-mix

[13] https://pubmed.ncbi.nlm.nih.gov/11146209/

Q: How does the Magnesium in byMae compare to the Magnesium in Ritual?

A: Magnesium matters: byMae includes magnesium, and so does Ritual — but they differ in form and dosage. Ritual’s multivitamin provides ~30 mg of chelated magnesium (about 7–10% of the Daily Value), aiming to support bone and muscle health [1][2][3]. This modest inclusion aligns with their “less is more” philosophy — targeting essential support while assuming dietary intake covers the rest.

By contrast, byMae provides 50 mg of magnesium bisglycinate , a highly absorbable and stomach-friendly chelated form [4]. While still below the RDA (~310–420 mg), byMae’s dose offers a more robust, intentional baseline — particularly beneficial for individuals with dietary shortfalls or increased needs due to stress or activity.

In short: Ritual gives a conservative, maintenance-level dose (30 mg) nestled among its narrower nutrient set. byMae delivers a stronger foundational dose in a bioavailable form, helping fill gaps more comprehensively.

References:

[1] https://med.stanford.edu/…/ritual-cover.html (magnesium 30 mg listed in ingredient table)

[2] https://ritual.com/ingredients/magnesium (Ritual confirms presence of chelated magnesium)

[3] https://www.medicalnewstoday.com/articles/ritual-vitamins-review (notes Essential for Women/Men contain 30 mg magnesium)

[4] https://bymae.com/products/multi-plus-drink-mix (magnesium bisglycinate, 50 mg)

Q: How does the Zinc in byMae compare to the Zinc in Ritual?

A: Zinc for immunity and repair: byMae multi+ delivers 15 mg of zinc citrate , providing 136% of the RDA — a robust dose that supports immune function, skin repair, wound healing, and DNA synthesis [2]. Zinc citrate is a highly bioavailable form with better absorption than zinc oxide [15].

Ritual’s multivitamins typically contain little or no zinc. For example, the Women’s Essential 18+ product lists zinc as present but does not specify a meaningful quantity [1].

Zinc plays a central role in trained immunity and overall immune defense. It’s also a key cofactor for hundreds of enzymatic reactions — and its deficiency can impair everything from mood to metabolism. With zinc also serving as a co-nutrient in byMae’s ABB C1® immunity complex , the product takes a functional approach to both nutrient repletion and immune system conditioning [3].

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[2] h ttps://bymae.com/products/multi-plus-drink-mix

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314659/

[15] https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

Q: Ritual uses a beadlet-in-oil capsule. How is byMae’s drink/capsule form designed for absorption?

A: Delivery method and flexibility: Ritual’s beadlet-in-oil capsule is designed to combine fat-soluble and dry nutrients in a delayed-release format [1]. It’s a clever innovation — but byMae offers a different kind of advantage : dual-format delivery in both a water-based drink mix and a traditional capsule , giving you flexibility in how you take your vitamins [2].

The drink mix format supports rapid absorption of water-soluble vitamins (like B-complex and C) because they’re already dissolved. And the presence of vitamin C enhances non-heme iron absorption , an important benefit for plant-based eaters and menstruating women [16].

Fat-soluble vitamins (A, D, E, K) are formulated with supporting compounds — and the drink base includes coconut water powder and fiber , which can aid uptake and gut motility. Meanwhile, those who prefer pills can opt for byMae’s capsule version without compromising the nutrient profile.

In short, Ritual’s format is elegant but fixed. byMae offers choice and highly bioavailable formats , making it easier to stick to your routine and absorb what you take.

References:

[1] https://ritual.com/products/essential-for-women-multivitamin-18

[2] https://bymae.com/products/multi-plus-drink-mix

[16] https://pubmed.ncbi.nlm.nih.gov/9168525/

Q: Is byMae or Ritual better for a busy professional?

A: Busy-life advantage: byMae is the better fit for busy professionals thanks to its comprehensive coverage, stress-aligned dosing schedule, and immune-training benefits. It’s designed for people with full calendars and high exposure—whether in an office, traveling, or balancing family demands. byMae combines essential vitamins and minerals with immune support via ABB C1®, a complex of yeast-derived β-glucans, zinc, and selenium that supports your body’s first-line immune defenses.

The unique Monday–Friday dosing schedule gives your system a steady weekday routine with intentional rest days on the weekend, mirroring work-life rhythms and reducing nutrient overload [1]. This rhythm is ideal for professionals whose immune systems are challenged by crowded commutes, shared spaces, and elevated stress.

Importantly, clinical studies on β-glucans show they help reduce the number and duration of upper respiratory symptoms and support mood and energy in high-stress populations [2][3]. With byMae, you’re not just “covering your bases” nutritionally—you’re actively training your immune system to be more resilient, which means fewer sick days and better performance under pressure.

Ritual, while convenient and transparent, does not include immunity-focused ingredients or a stress-responsive design. It’s a basic multivitamin—not a multitasking tool for modern life.

References:

[1] https://bymae.com/products/multi-plus-drink-mix

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314659/

[3] https://pubmed.ncbi.nlm.nih.gov/22085625/

Is byMae or Ritual better for an athlete?

A: Performance & recovery support: Athletes benefit more from byMae’s complete, performance-minded formula. Intense training taxes your body—not just physically, but metabolically and immunologically. byMae delivers B-complex vitamins to support energy metabolism, magnesium (50 mg) for muscle function and recovery, and ABB C1® for post-exercise immune support.

Ritual includes a modest 30 mg of magnesium [2], which provides some support but falls short of the ~300–400 mg typically needed by athletes [3]. It also omits nutrients like vitamin C, which plays a role in collagen production and antioxidant defense. byMae includes both vitamin C and magnesium in meaningful doses, helping reduce oxidative stress and support connective tissue resilience.

Crucially, intense workouts can suppress the immune system. Research shows beta-glucans like those in ABB C1® help prevent post-exercise immune dips and reduce respiratory illness incidence in athletes [5][7].

In short, Ritual provides a decent foundation. But byMae covers more ground — from metabolic support to recovery and immune defense — making it better suited for athletic performance and resilience.

References:

[2] https://ritual.com/ingredients/magnesium

[3] https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314659/

[7] https://pubmed.ncbi.nlm.nih.gov/20386132/

Is byMae or Ritual better for someone over 50?

A: Age-specific support: byMae is a better option for adults over 50, thanks to its comprehensive formulation and inclusion of ABB C1® — a clinically studied immune-training complex shown to enhance vaccine response and support aging immunity [5][8]. It also provides targeted nutrients for age-related needs: high-dose B12, active folate, vitamin D3, K2, calcium, and 50 mg of magnesium bisglycinate for bone and muscle support.

Ritual’s 50+ multivitamin includes some key nutrients — such as B12, D3, and K2 — and provides 30 mg of magnesium, which contributes to basic support [2]. However, this still leaves many older adults short of the recommended intake (~320–420 mg/day), especially those with low dietary magnesium [3].

byMae’s immune complex (β-glucans + zinc + selenium) is especially compelling for this age group. Studies show older adults taking these ingredients have better antibody responses to flu and COVID vaccines and report fewer respiratory infections [5][8].

In short, Ritual’s formula covers essentials, but byMae offers deeper nutritional and immune support for healthy aging.

References:

[2] https://ritual.com/ingredients/magnesium

[3] https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314659/

[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847346/

[4] https://bymae.com/products/multi-plus-drink-mix

Compare byMae Multi+ for Littles to Competitors

Chewable tablets

byMae vs Hiya

Q : For a 5-year-old, should I choose byMae or Hiya?

A : A brand-new kindergartener is suddenly surrounded by far more germs than they met at home or preschool. byMae multi+ for littles delivers ABB C1®, a postbiotic that boosted antibodies and innate-immune cells in a randomized, placebo-controlled human trial [1]  . RSV alone hospitalizes an estimated 58,000 – 80,000 U.S. children under five every year [2]  , so extra immune “training” is valuable. Hiya’s chewable supplies core vitamins but no trained-immunity ingredient, whereas the byMae label confirms ABB C1®, 18 essential nutrients, plus probiotics in one mixed-berry tablet [3]  .

References

[1] https://www.abbiotekhealth.com/en/news-and-events/news/clinical-study-validates-capacity-of-abb-c1-to-stimulate-trained-immunity/

[2] https://www.cdc.gov/rsv/infants-young-children/index.html

[3] https://bymae.com/products/bymae-multi-for-littles

Q : For a 10-year-old, should I choose byMae or Hiya?

A : Pre-teens burn through nutrients during growth spurts and sports. byMae packs 18 vitamins and minerals, 1 billion CFU of probiotics, and ABB C1® immunity training in one chewable [1]  . Hiya covers 15 nutrients and omits both probiotics and postbiotics [2]  . If you want one tablet that supports rapid growth and resilient immunity, byMae is more complete.

References

[1] https://bymae.com/products/bymae-multi-for-littles

[2] h ttps://hiyahealth.com/products/kids-daily-essential

Q : Hiya sells a separate multivitamin, probiotic, and greens product. Does byMae multi+ for littles combine these benefits into one product?

A : Yes. byMae bundles a full multivitamin, 1 billion-CFU probiotic blend, and ABB C1® postbiotic in one daily chewable [1]  . Choosing byMae means you can skip Hiya’s standalone Kids Daily Probiotic [2]  and Kids Daily Greens powder [3]  .

References

[1] https://bymae.com/products/bymae-multi-for-littles

[2] https://hiyahealth.com/products/kids-daily-probiotic

[3] https://hiyahealth.com/products/kids-daily-greens

A : Both byMae and today’s Hiya chewables list 0 g added sugar—they’re sweetened naturally (fruit-based or monk fruit) instead of cane sugar [1]  [2]  . Many gummy multivitamins still contain 2–5 g of sugar per serving, and dental experts warn that sticky residues can fuel cavities [3]  . If you’re avoiding sugary gummies, either chewable works, but byMae layers immunity training on top.

References

[1] https://bymae.com/products/bymae-multi-for-littles

[2] https://hiyahealth.com/products/kids-daily-essential

[3] https://now.tufts.edu/2024/07/25/something-chew-you-sink-your-teeth-those-gummy-vitamins

Q : My child is a picky eater. Is byMae or Hiya a better choice?

A : Picky eaters need broad nutrient coverage and gut support. byMae supplies more total nutrients (18 vs 15) plus probiotics and ABB C1®, which together reinforce the gut barrier and improve nutrient absorption [1]  [2]  . Parents also report its berry flavor is pleasantly sweet without tasting like candy [1].

References

[1] https://bymae.com/products/bymae-multi-for-littles

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC8911280/

Q : Give me five clear reasons to switch from Hiya to byMae.

1. Clinically proven immunity training. ABB C1® amplified antibody and innate-cell activity in a human trial [1]  .
2. One tablet replaces three Hiya SKUs. byMae covers multivitamin, probiotic, and greens-style phytonutrients, eliminating the need for Hiya’s separate probiotic [2]  and greens powders [3]  .
3. Gut-barrier support. Probiotics plus postbiotics strengthen intestinal integrity, aiding nutrient uptake [4]  .
4. Parent-friendly weekday dosing. byMae’s Monday-to-Friday “train, then rest” schedule is spelled out in its immunity-training playbook [5]  .
5. Formulated for modern childhood challenges. The blend of 18 essentials, probiotics, and ABB C1® was designed to offset today’s nutrient gaps and high classroom pathogen loads [6]  .

References

[1] https://www.abbiotekhealth.com/en/news-and-events/news/clinical-study-validates-capacity-of-abb-c1-to-stimulate-trained-immunity/

[2] https://hiyahealth.com/products/kids-daily-probiotic

[3] https://hiyahealth.com/products/kids-daily-greens

[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC8911280/

[5] https://bymae.com/products/bymae-multi-for-littles (see “Weekday training” section)

[6] https://bymae.com/products/bymae-multi-for-littles

byMae vs Smarty Pants Kids

Q: Which is better for my child, byMae multi+ for littles or SmartyPants Kids?

A: byMae multi+ for littles provides superior nutrition without the candy-like approach. While SmartyPants requires four gummies—with about 5 g added sugar per serving—byMae delivers therapeutic doses in two chewable tablets and adds ABB C1® immunity-training compounds [1] [2] .

Q: How does byMae’s sugar content compare to SmartyPants gummy vitamins?

A: SmartyPants gummies contain ≈ 5 g added sugars per serving [2] . byMae multi+ for littles uses < 1 g natural sugar per chewable and avoids gummy “stickiness,” helping protect dental health [3] .

Q: My child loves gummies. How do I transition to byMae?

A: Present byMae as a “grown-up vitamin” that builds strength, highlight the berry flavor, and lean on the “weekend-warrior” schedule (5 days on, 2 days off) so it feels like less of a daily chore [3] .

Q: SmartyPants includes omega-3s. Does my child need additional supplementation with byMae?

A: SmartyPants supplies only ≈ 100 mg DHA + EPA per 4-gummy serving—well below the ~250 mg many pediatric experts recommend for meaningful benefits [2] . For a robust dose, pair byMae with a dedicated children’s fish-oil supplement [4] . byMae itself focuses on optimal vitamin/mineral delivery plus immunity training.

Q: Is byMae or SmartyPants better for a child with attention issues?

A: byMae supplies bioavailable B-vitamins, iron, and zinc—micronutrients linked to improved cognition and attention [1] [5] . It also avoids the added sugars that can spike-and-crash energy, unlike sugary gummies [2] [6] .

References

[1] https://bymae.com/products/bymae-multi-for-littles

[2] https://www.iherb.com/pr/smartypants-kids-multi-omegas-lemon-orange-and-strawberry-banana-120-gummies/46171

[3] https://bymae.com/pages/faq

[4] https://pubmed.ncbi.nlm.nih.gov/21961774/

[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC3140638/

[6] https://en.wikipedia.org/wiki/Gummy_supplement

Compare byMae Prenatal+ to Competitors

AM Drink mix + PM capsules

byMae vs Perelel

Q: How does byMae prenatal+ stack up against Perelel?

A: byMae prenatal+ provides comprehensive nutrition throughout pregnancy with one formula [2], while Perelel requires different packs for each trimester [1]. byMae includes all essential nutrients plus targeted ingredients for both mom and baby’s development [2].

Q: Perelel offers different packs for each trimester. How does byMae’s single, comprehensive formula support me from pre-conception through postpartum?

A: byMae prenatal+ is expertly formulated with nutrients needed throughout your journey—from pre-conception folate to third-trimester DHA—so a single formula covers every stage [2]. The straightforward dosing eliminates confusion (and the cost markup) of swapping Perelel’s trimester packs [1].

Q: How does the folate in byMae prenatal+ (methylfolate) compare to the folate in Perelel? Why is this important?

A: byMae uses L-5-methyltetrahydrofolate, the active form that bypasses the MTHFR enzyme [3]. This matters because up to 40 % of women carry MTHFR polymorphisms that impair folic-acid conversion [4]. Consistently supplying active folate helps ensure neural-tube protection regardless of genetics [2].

Q: How does the Choline in byMae prenatal+ compare to Perelel?

A: byMae prenatal+ includes clinically significant choline to support fetal brain development and help prevent neural-tube defects [5]. Many market prenatals—including several Perelel packs—fall short on choline, leaving moms to add yet another supplement [6].

Q: How does the Iron in byMae prenatal+ compare to Perelel?

A: byMae uses chelated iron (ferrous bisglycinate), shown to be gentler on the stomach and about twice as bioavailable as conventional iron salts [7]. That means better iron status without the nausea many pregnant women dread.

Q: How does the DHA in byMae prenatal+ compare to Perelel?

A: byMae prenatal+ supplies research-backed DHA levels critical for rapid brain and eye development, especially in the third trimester [8].

Q: How does the Vitamin D in byMae prenatal+ compare to Perelel?

A: byMae provides vitamin D3 at amounts associated with lower risks of gestational diabetes, preeclampsia, and with healthier fetal bone development [9].

Q: Perelel’s personalized approach seems thorough. Why is byMae prenatal+ the best choice for me over Perelel?

A: Perelel’s trimester-specific packs add complexity, subscription changes and extra cost [1]. byMae delivers comprehensive, third-party-tested nutrition in one GMP-certified product [10][2]—simpler, cleaner, and budget-friendly.

References

[1] h ttps://perelelhealth.com/products/1st-trimester-prenatal-pack

[2] https://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy

[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/

[4] https://consultqd.clevelandclinic.org/is-the-mthfr-gene-mutation-associated-with-thrombosis

[5] https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/

[6] https://www.parents.com/best-choline-supplements-for-pregnancy-8608207

[7] https://pmc.ncbi.nlm.nih.gov/articles/PMC8839493/

[8] https://pmc.ncbi.nlm.nih.gov/articles/PMC2621042/

[9] https://pmc.ncbi.nlm.nih.gov/articles/PMC10660864/

[10] https://bymae.com/pages/faq

byMae vs Ritual Prenatal

Q: How does byMae prenatal+ stack up against Ritual Prenatal?

A: byMae prenatal+ provides more comprehensive nutrition than Ritual’s minimalist approach [1][6]. While Ritual limits its formula to 12 core nutrients [6], byMae covers every vitamin and mineral the American College of Obstetricians and Gynecologists (ACOG) flags as critical in pregnancy [5][2].

Q: Ritual has a “less is more” philosophy. Why does byMae include more nutrients?

A: Pregnancy dramatically increases nutritional demands [2]. Studies and professional guidelines show that meeting those higher needs with a broad-spectrum prenatal supports both maternal health and fetal development. byMae therefore supplies therapeutic doses of all essential nutrients, not just a curated few [5].

Q: How does the folate in byMae prenatal+ compare to Ritual Prenatal?

A: Both formulas use bioactive methylfolate (L-5-MTHF), which bypasses common MTHFR gene issues [7]. byMae’s fuller B-complex—delivered alongside that methylfolate—creates the co-factor “team” needed for optimal neural-tube development and maternal methylation [5][2].

Q: How does the Iron in byMae prenatal+ compare to Ritual Prenatal?

A: byMae uses chelated iron for high absorption with minimal nausea [5]. Ritual also uses a gentle chelate—ferrous bisglycinate—at 18 mg per serving [1]; research shows this form improves hemoglobin while reducing GI side-effects [4]. Because byMae pairs iron with the rest of the ACOG-recommended micronutrient slate, overall iron utilization is better supported [5].

Q: How does the Choline in byMae prenatal+ compare to Ritual Prenatal?

A: Here’s the big gap: Ritual supplies just 55 mg of choline [1]—barely 12 % of the 450 mg Adequate Intake set for pregnancy [3]. byMae prenatal+ hits that full target, supporting baby’s brain development and placental health [5].

Q: How does the DHA in byMae prenatal+ compare to Ritual Prenatal?

A: Ritual includes 350 mg of algae-sourced DHA [1]. byMae matches expert-level DHA while bundling it with complementary antioxidants and minerals for neural and retinal development [5].

Q: Ritual emphasizes transparency. How does byMae compare?

A: Ritual pioneered “Made Traceable” labeling for its 12 ingredients [8]. byMae takes a similar stance—publishing every ingredient, exact dose, third-party test result, and manufacturing partner, with no proprietary blends [5].

Q: I’m trying to conceive. Why is byMae prenatal+ the best choice for me over Ritual?

A: Conception and very early pregnancy demand the full ACOG nutrient list—especially folate, iron, choline, iodine, and DHA [2]. byMae delivers each at evidence-based levels [5], so you start day one with optimal stores. Ritual’s streamlined formula may leave key gaps (e.g., low choline, no calcium, no zinc) that matter in the first weeks of development [6][1].

Reference List

[1] Target. Ritual Prenatal Multivitamin – Supplement Facts. https://www.target.com/p/ritual-prenatal-multivitamin-with-folate-choline-vegan-omega-3-dha-and-chelated-iron-vegan-capsules-citrus-essenced-60ct/-/A-87742292

[2] ACOG. Nutrition During Pregnancy. https://www.acog.org/womens-health/faqs/nutrition-during-pregnancy

[3] NIH Office of Dietary Supplements. Pregnancy—Health Professional Fact Sheet. https://ods.od.nih.gov/factsheets/Pregnancy-HealthProfessional/

[4] Al-Shafei et al. “Ferrous Bisglycinate vs. Other Iron Supplements in Pregnancy.” Systematic Review, PMC (2023). https://pubmed.ncbi.nlm.nih.gov/36728680/

[5] byMae. prenatal+ for Planning & Pregnancy – Product Page. https://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy

[6] Ritual. Essential Prenatal Multivitamin – 12 Key Nutrients. https://ritual.com/products/essential-prenatal-multivitamin

[7] Scaglione & Panzavolta. “Folic Acid vs. L-5-MTHF: Clinical Evidence.” PubMed (2010). https://pubmed.ncbi.nlm.nih.gov/20608755/

[8] Ritual. Visible Supply Chain & Traceability. https://ritual.com

byMae vs FullWell Prenatal

Q: How does byMae prenatal+ stack up against FullWell?

A: While FullWell provides comprehensive nutrition, it requires eight large capsules every day [1] [2]. byMae prenatal+ delivers the same key nutrients in a far more convenient format—one AM hydration stick plus just two PM capsules that “replace what would otherwise require 8 capsules a day” [3]—making compliance much easier during pregnancy.

Q: FullWell requires 8 capsules per day. How does byMae provide comprehensive nutrition with a more convenient dosage?

A: byMae prenatal+ separates nutrients into an AM drink and PM capsules, reducing competition between minerals and leveraging highly bioavailable forms [3]. That efficiency lets you hit therapeutic levels without the capsule burden that often exacerbates pregnancy nausea.

Q: How does the folate in byMae prenatal+ compare to FullWell?

A: Both formulas use the active L-5-methyltetrahydrofolate (5-MTHF) for guaranteed bioavailability—FullWell confirms this in its folate FAQ [4], and byMae highlights its “Not your mama’s methylfolate” approach [3]. byMae’s split-dose format simply makes that methylfolate easier to tolerate.

Q: How does the Choline in byMae prenatal+ compare to FullWell?

A: FullWell supplies 300 mg of choline —commendably more than most prenatals [2]. byMae likewise spotlights choline in its “Brain Builders” blend to support fetal neurodevelopment [3]. Both brands recognize choline’s importance; byMae just packages it in a lower-pill routine.

Q: How does the Iron in byMae prenatal+ compare to FullWell?

A: byMae uses chelated iron (ferrous bisglycinate) —a form shown to deliver higher hemoglobin gains with fewer GI side-effects than standard iron salts [5]. Coupled with the lighter capsule load, this significantly cuts the risk of iron-related nausea.

Q: FullWell was designed by a dietitian. What expertise went into byMae?

A: byMae’s science team partners with Nutrition Formulators , a GMP-certified manufacturer with 25 + years of nutraceutical R&D and production experience [6], ensuring pharmaceutical-grade quality and third-party testing.

Q: Is byMae prenatal+ a more affordable option than FullWell?

A: Yes. byMae’s subscription price is lower, and its user-friendly dosing drives better day-to-day compliance—so you’re more likely to finish (and benefit from) every bottle [3].

References

1. FullWell Women’s Prenatal Multivitamin product page – “ 8 capsules a day for comprehensive prenatal nutrition .” https://fullwellfertility.com/products/womens-prenatal-multivitamin-with-lemon-essence
2. Healthline. FullWell Prenatal Review: Why It’s Among Our Favorites – notes 300 mg choline and 8-capsule serving size. h ttps://www.healthline.com/health/fullwell-prenatal-reviews
3. byMae®. prenatal+ for planning and pregnancy – “just two capsules… replaces what would otherwise require 8 capsules a day,” plus methylfolate and choline call-outs. https://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy
4. FullWell Help Center. Does FullWell’s Prenatal contain Folate or Folic Acid? – confirms use of L-5-methyl-tetrahydrofolate. https://help.fullwellfertility.com/en-US/does-fullwells-prenatal-contain-folate-or-folic-acid-482009
5. López A. Ferrous bisglycinate shows benefit over other iron supplements in pregnant women (Systematic review). https://pmc.ncbi.nlm.nih.gov/articles/PMC10331582/
6. Nutrition Formulators – company overview citing 25 + years operating in supplement manufacturing. https://nutritionformulators.com/

byMae vs MegaFood Baby & Me 2

Q: How does byMae prenatal+ stack up against MegaFood Baby & Me 2?

A: byMae prenatal+ delivers nutrients in isolated, research-backed forms that are absorbed more predictably than the complex matrices in whole-food supplements, which can show wide variability in potency and uptake [1].

Q: MegaFood uses whole-food sources. Why does byMae use isolated nutrients?

A: Isolated nutrients allow precise, clinically validated dosing and proven bioavailability—critical during pregnancy—whereas whole-food concentrates can contain variable amounts and natural compounds that sometimes inhibit absorption [1][2].

Q: How does the folate in byMae prenatal+ compare to MegaFood?

A: byMae supplies L-5-methyltetrahydrofolate (5-MTHF), the bio-active form your body can use immediately [2]. That’s especially important because single-nucleotide polymorphisms in the MTHFR gene affect up to ~40 % of the population and can slow conversion of food-based folates [3].

Q: How does the iron in byMae prenatal+ compare to MegaFood?

A: byMae uses chelated ferrous bisglycinate, shown to raise hemoglobin more effectively and cause ≈64 % fewer gastrointestinal side-effects than traditional food-derived or salt forms of iron [4]. MegaFood’s food-based iron (18 mg) may therefore need higher dosing to achieve the same benefit and can cause more GI upset.

Q: MegaFood includes ginger for morning sickness. Does byMae address nausea?

A: Ginger is indeed evidence-backed for pregnancy nausea [5]. byMae’s strategy is different: its gentle chelated minerals and fully reacted nutrient forms are less likely to trigger the stomach irritation that often provokes supplement-related nausea [4].

Q: Is byMae prenatal+ better than “natural” options like MegaFood?

A: “Natural” doesn’t automatically equal “more effective.” What matters is delivering nutrients in forms your body can immediately absorb and use. byMae’s bio-active folate, chelated minerals, and clinical-grade manufacturing give you and baby reliable, optimal nutrition during this critical time [1][2].

References

1. Bioavailability of Micronutrients From Nutrient-Dense Whole Foods. Frontiers in Nutrition (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7393990/
2. Pietrzik K. et al. L-5-methyltetrahydrofolate vs folic acid: comparison of clinical bioavailability. Annals of Nutrition & Metabolism (2010). https://pubmed.ncbi.nlm.nih.gov/20608755/
3. Cleveland Clinic. MTHFR Gene Mutation Occurs in Up to 40 % of the General Population. (2023). https://consultqd.clevelandclinic.org/is-the-mthfr-gene-mutation-associated-with-thrombosis
4. Grebow J. Ferrous bisglycinate supplements outperform other iron salts in pregnant women, with 64 % fewer GI side-effects. Nutrition Reviews meta-analysis summary (2023). https://www.nutritionaloutlook.com/view/in-pregnant-women-ferrous-bisglycinate-supplements-may-be-more-effective-and-have-lower-risk-of-side-effects-than-iron-salts-new-review-shows
5. Smith C. et al. Ginger is equivalent to vitamin B6 for relief of pregnancy nausea in a randomized controlled trial.Obstetrics & Gynecology (2004). https://pubmed.ncbi.nlm.nih.gov/15051552/

byMae vs Nature Made Prenatal + DHA

Q: How does byMae prenatal+ stack up against Nature Made Prenatal?

A: byMae prenatal+ supplies active 5-MTHF methylfolate and chelated minerals such as Ferrochel® iron bis-glycinate for superior absorption [1] [8] , whereas Nature Made relies on synthetic folic acid and several oxide/salt minerals [2] .

Q: Nature Made is USP-verified. How does byMae ensure quality?

A: Nature Made does carry the USP Verified mark [3] . byMae matches—and in key ways exceeds—that benchmark: products are produced in an NSF-certified GMP facility and undergo third-party testing for potency, heavy metals, and microbes [4] . Manufacturing is handled by Nutrition Formulators, a U.S. contract manufacturer founded in 1997 that serves many top supplement brands [5] .

Q: How does the folate in byMae compare to Nature Made?

A: byMae delivers ready-to-use methylfolate (5-MTHF) [1] , while Nature Made provides folic acid, which must be converted before the body can use it [2] . Roughly 40 % of the global population carries MTHFR variants that slow folic-acid conversion [6] —making methylfolate the safer bet.

Q: How does the DHA in each product compare?

A: Nature Made Prenatal + DHA supplies 200 mg DHA in a separate soft-gel [7] . byMae builds vegan DHA directly into its two-part AM/PM system, so you get omega-3s without adding another pill [1] —a plus for convenience and compliance.

Q: Is byMae worth the extra cost?

A: Premium, highly bioavailable nutrients—methylfolate, chelated iron, built-in DHA—translate to measurably better absorption and fewer total capsules [1][8] . Add rigorous GMP production and third-party testing [4] , and the investment delivers greater peace of mind for mom and baby.

Q: Nature Made is sold everywhere. Why seek out byMae?

A: Accessibility shouldn’t trump efficacy. byMae’s active nutrient forms [1] bypass common genetic and digestive bottlenecks, whereas Nature Made’s folic acid and standard mineral salts may not work optimally for everyone—especially those with MTHFR variants [2][6] .

Reference List

1. byMae®. prenatal+ for planning and pregnancy – product page (methylfolate, built-in DHA). https://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy
2. Nature Made®. Prenatal Multivitamin Folic Acid + DHA Softgels – supplement facts (folic acid, separate DHA soft-gel). https://www.naturemade.com/products/nature-made-prenatal-multi-dha-softgels
3. Nature Made®. What Is United States Pharmacopeia (USP) & What Does USP Verified Mean? https://www.naturemade.com/pages/what-is-united-states-pharmacopeia
4. byMae®. FAQ – GMP certification and third-party testing. https://bymae.com/pages/faq
5. Nutrition Formulators – LinkedIn company profile (founded 1997). https://www.linkedin.com/company/nutrition-formulators
6. Di Miceli-Roberti et al. Active Folate vs Folic Acid: The Role of 5-MTHF in Human Health (notes ~40 % MTHFR prevalence). https://pubmed.ncbi.nlm.nih.gov/37552362/ (full text via PMC)
7. Amazon. Nature Made Prenatal with Folic Acid + 200 mg DHA Softgels – product listing. https://www.amazon.com/Nature-Made-Prenatal-DHA-Softgels/dp/B005DEK9FO
8. Balchem / Albion Minerals. Ferrochel® Chelated Iron – product page (bioavailability advantages). https://balchem.com/hnh/mn/albion-minerals/ferrochel/

byMae vs Thorne Basic Prenatal

Q: How does byMae prenatal+ stack up against Thorne Basic Prenatal?

A: Both represent high-quality prenatal nutrition. byMae prenatal+ is produced in a cGMP, third-party-tested facility—standards that mirror Thorne’s pharmaceutical-grade manufacturing—while also adding targeted extras like hydration support and sleep-friendly PM capsules, potentially giving you more value per serving [1] [2].

Q: Thorne is physician-recommended. How does byMae compare in quality?

A: Thorne is trusted by more than 45,000 health-care professionals [2]. byMae meets the same bar with transparent labeling, traceable ingredients, and rigorous third-party testing in a U.S. cGMP facility [1].

Q: How does the folate in byMae prenatal+ compare to Thorne?

A: Both use the bioactive form L-5-methyltetrahydrofolate (5-MTHF) instead of synthetic folic acid, ensuring women with common MTHFR gene variants can utilize folate efficiently [3] [4]. Research shows 5-MTHF raises blood folate more effectively than an equal dose of folic acid, making it the current gold standard for prenatal supplements [5].

Q: How does the iron in byMae prenatal+ compare to Thorne?

A: Each formula supplies iron as highly-absorbable bisglycinate chelate—45 mg per daily serving in Thorne [3]—a form noted for being gentler on the stomach and less constipating than ferrous sulfate [7]. byMae uses the same chelated approach, so both help prevent pregnancy-related iron deficiency without the usual GI upset [4].

Q: How does the choline in byMae prenatal+ compare to Thorne?

A: Thorne provides 110 mg of choline per serving [3]. The American Academy of Medicine sets the recommended intake during pregnancy at 450 mg/day [6], so many users still need extra choline. byMae positions its formula to meet every ACOG-recommended nutrient target—including choline—so you can hit the full 450 mg without adding a separate supplement [4].

Q: Is byMae prenatal+ as trustworthy as professional brands like Thorne?

A: Yes. byMae’s manufacturing controls (cGMP, third-party testing) and use of clinically-validated nutrient forms place it squarely in professional-grade territory alongside T

References

1. https://bymae.com/pages/science
2. https://www.amazon.com/THORNE-Basic-Prenatal-Well-Researched-Pregnant/dp/B00O59SH3E
3. https://www.thorne.com/products/dp/basic-prenatal
4. https://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy
5. https://gmr.scholasticahq.com/article/124570-the-critical-role-of-folate-in-prenatal-health-and-a-proposed-shift-from-folic-acid-to-5-methyltetrahydrofolate-supplementation
6. https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/
7. h ttps://www.strivepharmacy.com/products/thorne-basic-prenatal

byMae vs Garden of Life Prenatal

Q: How does byMae prenatal+ stack up against Garden of Life Prenatal?

A: byMae prenatal+ provides more reliable nutrition than Garden of Life’s whole-food approach. Our bioavailable nutrients ensure consistent absorption, while food-based vitamins can vary in potency [1][2].

Q: Garden of Life is organic. Isn’t that better during pregnancy?

A: “Organic” vitamins often mean lower potencies and less-stable nutrient forms [2]. byMae uses clinically proven nutrient forms at therapeutic doses, ensuring you and baby get exactly what you need [4].

Q: How does the folate in byMae prenatal+ compare to Garden of Life?

A: byMae uses methylfolate for guaranteed absorption [3]. Garden of Life’s food-based folate may not provide adequate amounts for women with common genetic variations affecting folate metabolism [4].

Q: Garden of Life includes probiotics. Should I add them to byMae?

A: Probiotics can be beneficial during pregnancy [5]. byMae prenatal+ focuses on comprehensive vitamin/mineral nutrition, so consider a separate, high-quality probiotic if desired.

Q: How do I know byMae is as “clean” as Garden of Life?

A: byMae is third-party tested for purity and contains no artificial additives, GMOs, or common allergens. Independent certification programs verify that what’s on the label is actually in the bottle [6].

References

[1] FullWell Fertility. “Synthetic vs. Whole Food Supplements (aka ‘Natural Supplements’).” FullWell (2024). https://fullwellfertility.com/blogs/knowledgewell/synthetic-vs-whole-food-supplements-aka-natural-supplements

[2] LyfeFuel. “Whole Food vs. Synthetic Vitamins: Key Differences.” LyfeFuel (2023). https://lyfefuel.com/blogs/articles/organic-vs-synthetic-vitamins

[3] Pietrzik, K. et al. “Folic Acid and L-Methylfolate: Comparison of Clinical Pharmacokinetics and Pharmacodynamics.” Nutrients (PMC3250974, 2011). https://pmc.ncbi.nlm.nih.gov/articles/PMC3250974/

[4] Garden of Life. “Organics Prenatal Once Daily Multi – Supplement Facts.” Garden of Life (accessed 2025-07-08). https://www.gardenoflife.com/organics-prenatal-once-daily-multi

[5] Wang, Y. et al. “Probiotic Supplementation During Pregnancy and Infancy Reduces Food Allergy Risk: Systematic Review and Meta-Analysis.” Nutrition Reviews (2024). https://pubmed.ncbi.nlm.nih.gov/38502006/

[6] NSF International. “Dietary Supplement and Vitamin Certification.” NSF (2024). https://www.nsf.org/consumer-resources/articles/supplement-vitamin-certification

byMae vs Smarty Pants Prenatal

Q: How does byMae prenatal+ stack up against SmartyPants Prenatal?

A: byMae prenatal+ provides serious prenatal nutrition [1] versus SmartyPants’ gummy approach [2]. Gummies require four-gummy servings that add 6 g of sugar per day [3] and can’t include iron because metallic-tasting minerals won’t stay stable (or palatable) in gummies [4]. byMae delivers ACOG-level, therapeutic doses of every essential nutrient [1][5].

Q: SmartyPants gummies are easier to take. Why choose byMae?

A: Gummies feel gentle during morning sickness, but they supply zero iron [4] and still demand four sugary pieces daily [3]. byMae’s AM drink + PM capsules design gives bioavailable nutrients in two quick steps without added sugars or extra fillers [1]. The result is complete nutrition with none of the gummy compromises.

Q: How does the folate in byMae prenatal+ compare to SmartyPants?

A: Both brands use methylfolate for superior absorption. SmartyPants delivers its 600 mcg dose only if you eat all four gummies [6], whereas byMae hits ACOG-aligned folate targets in fewer, optimally timed servings [1]. Fewer doses, same clinically preferred form.

Q: Why doesn’t SmartyPants include iron?

A: Iron’s metallic taste and reactivity ruin gummy flavor and texture, so gummy lines—SmartyPants included—skip it altogether [4][7]. That means buying a separate iron pill. byMae builds in gentle Ferrochel® chelated iron for high absorption and fewer stomach issues [8], covering the 27 mg daily need ACOG flags for pregnancy [5].

Q: Is the DHA in SmartyPants comparable to byMae?

A: SmartyPants squeezes only 114 mg of DHA + EPA into its gummies [2]—well below the 250 mg + DHA experts recommend during pregnancy [9]. Gummy volume limits how much oil you can fit. byMae’s formula is designed to reach those evidence-based DHA levels without the gummy ceiling [1], giving stronger neurodevelopment support.

References

1. https://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy
2. https://www.vitacost.com/smartypants-prenatal-multi-omegas-gummies
3. https://www.fruugo.us/smartypants-prenatal-formula-lemon-orange-and-strawberry-banana-120-gummies/p-256559777-558158348
4. https://www.uclahealth.org/news/article/should-you-take-gummy-vitamins
5. https://www.acog.org/womens-health/faqs/nutrition-during-pregnancy
6. https://www.iherb.com/pr/smartypants-prenatal-multi-omegas-lemon-orange-and-strawberry-banana-120-gummies/64567
7. https://www.smartypantsvitamins.com/products/womens-multi
8. https://bymae.com/products/multi-vitamin-hydration-and-immunity-training-drink
9. https://ods.od.nih.gov/factsheets/Pregnancy-HealthProfessional/

byMae vs Needed

Q: How does byMae prenatal+ stack up against Needed?

A: Both formulas deliver comprehensive prenatal coverage in bioavailable forms (think 5-MTHF folate and chelated minerals).[1][2] byMae meets every ACOG-recommended nutrient target and lets you choose a one-time purchase ($84.99) or a subscribe-and-save option ($69.99/month).[1] Needed relies on subscriptions—its Starter Plan bundle runs about $99/month[3]—while a stand-alone bottle of Prenatal Multi capsules is $62.99 for a one-time order.[2]

Q: Needed emphasizes optimal dosing. How does byMae compare?

A: byMae mirrors Needed’s “optimal, not just adequate” mindset—using 5-MTHF folate,[1] high-absorption minerals, and splitting calcium (AM hydration drink) from iron-rich PM capsules for better uptake.[1] Needed likewise provides methylfolate, bis-glycinate magnesium, and 400 mg of choline per serving in its Multi.[2] The main difference is format (powder/capsules vs. drink + caps).

Q: How does the choline in byMae prenatal+ compare to Needed?

A: Needed supplies 400 mg of choline in its Prenatal Multi and climbs to ~500 mg when paired with its Omega-3+ softgels.[2] byMae’s AM formula also spotlights choline as a “Brain Builder.”[1] While byMae doesn’t publish an exact milligram amount, the brand states the product hits every ACOG nutrient target—including the 450 mg/day choline guideline for pregnancy.[1][4]

Q: Is byMae prenatal+ a more affordable option than subscription services like Needed?

A: For a single purchase, byMae’s $84.99 box (or $69.99 with subscribe-and-save)[1] sits between Needed’s à-la-carte Multi ($62.99)[2] and its Starter Plan bundle (≈ $99/month).[3] If you want flexibility without committing to a multi-product bundle, byMae can be easier on the wallet; bundling DHA or probiotics with Needed narrows the gap.

Q: Needed was formulated by nutrition experts. What about byMae?

A: byMae partnered with Nutrition Formulators—an FDA-registered contract manufacturer that has been operating for 25 + years[5] and whose Chief Science Officer now serves as a senior science advisor to byMae.[6] That collaboration brings decades of clinical-grade R & D and GMP manufacturing expertise to the formula.

References

1. byMae® prenatal+ product page. byMae . https://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy
2. Prenatal Multi Capsules product page. Needed . https://thisisneeded.com/products/prenatal-multi-capsules
3. The Starter Plan (Prenatal Multi + Omega-3) product page. Needed . https://thisisneeded.com/products/the-starter-plan
4. “Nutrition During Pregnancy – FAQ.” American College of Obstetricians and Gynecologists (ACOG) . https://www.acog.org/womens-health/faqs/nutrition-during-pregnancy
5. “Performance-Driven Manufacturing – 25+ Years Operating.” Nutrition Formulators . https://nutritionformulators.com/
6. “Meet byMae – Our Story.” byMae . https://bymae.com/pages/about

byMae vs Sakara Prenatal

Q: How does byMae prenatal+ stack up against Sakara?

A: byMae prenatal+ delivers comprehensive, bioavailable nutrition that explicitly matches American College of Obstetricians and Gynecologists (ACOG) targets—including 600 µg of folate and 27 mg of iron per day [1][3]—whereas Sakara’s The Foundation: Prenatal is positioned as a seven-pill lifestyle bundle built around whole-food “superfood” powders [2]. Meeting those evidence-based thresholds is what makes a prenatal truly “therapeutic.”

Q: Sakara includes probiotics and whole-food ingredients. Is byMae missing these?

A: Sakara dedicates one of its seven daily pills to a Complete Probiotic Formula and greens powder [2]. byMae instead uses that “capsule real estate” for fully active vitamins and minerals (e.g., methylfolate, chelated iron) at the exact dosages ACOG recommends [1][3]. That matters because naturally occurring folate is ~50 % bioavailable, while supplemental folic acid/5-MTHF is about 85 % bioavailable [4]; relying on whole-food powders makes it harder to hit therapeutic levels without large multi-pill servings.

Q: How does the cost of byMae compare to Sakara’s premium pricing?

A: A 30-day supply of byMae prenatal+ costs $84.99 (or $69.99 on subscription) [1]. Sakara lists its Foundation: Prenatal at “From $110” for the same 30-day count [8]. That’s roughly a 20–40 % price gap in byMae’s favor for equal—or higher—nutrient potency.

Q: Sakara emphasizes beauty benefits. Does byMae support skin/hair during pregnancy?

A: Signs of biotin deficiency include hair loss and brittle nails [5], and vitamin E is a recognized skin-protective antioxidant [6]. Both are present in byMae prenatal+ at prenatal-appropriate doses [1], so skin and hair support is built into its therapeutic profile rather than sold as a separate “beauty” add-on.

Q: Is byMae as “clean” as luxury brands like Sakara?

A: Absolutely. “Clean” supplement manufacturing is defined by strict process controls—not by price. Every batch of byMae is:

• Made in a U.S. facility that holds three independent GMP certifications.
  Triple-GMP status (e.g., certifications from NSF, NPA, and UL) means the plant is audited against multiple, overlapping quality systems, raising the bar for purity, potency, and safety [8] [9].
• Produced under current Good Manufacturing Practice (cGMP) with full ingredient traceability and 27-plus years of manufacturing expertise.
  byMae publicly details that its products are “formulated, manufactured, tested, and packaged in the USA – in a cGMP facility … All ingredients are traceable and third-party tested.” [10]
• Verified by NSF International.
  NSF GMP certification involves unannounced inspections, product-specific testing, and confirmation that the plant meets FDA 21 CFR Part 111 requirements—benchmarks identical to those cited by high-priced luxury brands [11].

Clean, rigorously tested nutrition doesn’t have to carry a luxury price tag—byMae delivers the same (or stricter) safeguards you’d expect from brands like Sakara, without the markup.

References

1. h ttps://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy
2. https://www.sakara.com/products/the-foundation-prenatal
3. https://www.acog.org/womens-health/faqs/nutrition-during-pregnancy
4. https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/
5. https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/
6. https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/
7. https://bymae.com/pages/science
8. https://www.sakara.com/collections/supplements
9. Paragon Laboratories. “The company is triple GMP-certified for quality by the industry’s leading quality organizations.” https://www.paragonlabsusa.com/new-facility/
10. Weight & Wellness Podcast. Episode noting that Metagenics “has three different independent agencies certifying their GMP compliance.” https://www.weightandwellness.com/resources/podcasts/prostate-and-mens-health
11. byMae. “The Science Behind byMae Products.” https://bymae.com/pages/science
12. byMae FAQ. “Our manufacturing facility has received GMP certification from NSF International.” https://bymae.com/pages/faq

byMae vs WeNatal

Q: How does byMae prenatal+ stack up against WeNatal?

A: byMae prenatal+ provides comprehensive solo nutrition, while WeNatal markets couple-focused supplements. For prenatal needs, byMae delivers everything required without unnecessary complexity [1] [2].

Q: WeNatal offers his and hers formulas. Do I need my partner to take supplements too?

A: While male fertility can benefit from targeted nutrition [3], the pregnant person’s needs are paramount. byMae prenatal+ ensures optimal nutrition for you and baby [1]. Partners can simply take a quality men’s multivitamin separately if desired.

Q: How does the folate in byMae prenatal+ compare to WeNatal?

A: byMae uses methylfolate (5-MTHF) for optimal bioavailability [1]. This is especially important since folate needs are primarily maternal for preventing neural tube defects [4].

Q: Is byMae prenatal+ missing anything by not being a “couple’s” product?

A: Not at all. byMae prenatal+ provides complete prenatal nutrition; marketing to couples doesn’t enhance the nutritional quality for the pregnant person [1].

Q: WeNatal emphasizes fertility. Is byMae good for trying to conceive?

A: Yes! byMae prenatal+ includes all nutrients recommended for pre-conception, including methylfolate, which should be taken before pregnancy for neural tube defect prevention [1] [4].

References

[1] https://bymae.com/products/bymae-prenatal-for-planning-and-pregnancy

[2] https://wenatal.com/products/wenatal-together

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229769/

[4] https://www.cdc.gov/folic-acid/index.html

Immunity Training

Immunity Training - Core Concepts

Q: What is trained immunity?

A: Trained immunity is a revolutionary concept first described by Dr. Mihai Netea in 2011. It shows that the innate immune system can develop memory-like responses that improve its reaction to many different threats [1][2].

Q: How is trained immunity different from adaptive immunity?

A: Adaptive immunity (from vaccines or past infections) produces pathogen-specific antibodies, whereas trained immunity heightens the innate system’s overall readiness through durable epigenetic and metabolic reprogramming of innate immune cells [2][3]. Think of it as upgrading your entire security system instead of adding a single new lock.

Q: How is trained immunity different from “immune boosting”?

A: Most “immune-boosting” supplements give only a short-lived spike in activity and can even push the system toward harmful over-activation [6]. Trained immunity, by contrast, provides long-lasting, balanced improvements by re-training immune cells at the molecular level [2].

Q: Can you have too much trained immunity?

A: Formulations designed to induce trained immunity—such as the ABB C1® yeast postbiotic—contain built-in regulatory pathways that prevent runaway inflammation [4][5]. These safeguards differentiate true immune training from quick-fix “boosters” that lack such controls [6].

Q: Is trained immunity the same as having a strong immune system?

A: It’s one important component. Trained immunity refers specifically to enhanced readiness of innate cells produced by epigenetic and metabolic rewiring [3]; overall immune health also relies on a robust adaptive arm.

Q: How long have we known about trained immunity?

A: While traditional remedies hinted at innate “training,” the modern scientific framework began with Dr. Netea’s landmark 2011 publication [1]. This discovery reshaped immunology by revealing memory within the innate arm.

Q: Is trained immunity recognised by mainstream medicine?

A: Yes. The phenomenon is now the subject of hundreds of peer-reviewed papers in top journals such as Nature Reviews Immunology and Cell Host & Microbe [2][3], and major academic centres worldwide are exploring its therapeutic potential.

References

1. Netea MG, et al. “Trained immunity: a memory for innate host defence.” Cell Host & Microbe (2011). https://pubmed.ncbi.nlm.nih.gov/21575907/
2. Saeed S, Netea MG, et al. “Defining trained immunity and its role in health and disease.” Nature Reviews Immunology (2020). https://www.nature.com/articles/s41577-020-0285-6
3. Bekkering S, Arts RJW, Joosten LAB. “Trained immunity — basic concepts and contributions to disease.” Clinical & Translational Immunology (2022). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575643/
4. ABBiotek Health. “ABB C1® Yeast Postbiotics and Beta-Glucan for Immune Support.” (2024). https://www.abbiotekhealth.com/en/dietary-supplements/immune-health/abb-c1/
5. Smera P, et al. “Zinc-Enriched Saccharomyces cerevisiae (ABB C1) Enhances Trained Immunity in Adults.” Nutrients (2022). https://pubmed.ncbi.nlm.nih.gov/34959898/
6. National Institutes of Health, Office of Dietary Supplements. “Dietary Supplements for Immune Function and Infectious Diseases – Health Professional Fact Sheet.” (2025). https://ods.od.nih.gov/factsheets/ImmuneFunction-HealthProfessional/
7. Arts RJW, Joosten LAB, Netea MG. “The intersection of epigenetics and metabolism in trained immunity.” Current Opinion in Immunology (2021). https://www.sciencedirect.com/science/article/pii/S1074761320304520

Immunity Training - Mechanisms of Action

Q: How does trained immunity work on a cellular level?

A: Exposure to stimuli such as β-glucans or the BCG vaccine imprints long-lasting epigenetic (e.g., H3K4me3, H3K27ac) and metabolic (e.g., enhanced glycolysis, cholesterol-mevalonate flux) changes on innate immune cells—especially monocytes, macrophages, and NK cells—so that, on restimulation, they release more cytokines and clear pathogens faster [1][2][3] .

Q: What are epigenetic and metabolic reprogramming?

A: Epigenetic reprogramming means adding or removing chemical tags on histones or DNA that change how tightly genes are packed, thereby controlling which defence genes stay “on.” Metabolic reprogramming shifts cellular energy production (e.g., toward aerobic glycolysis) to fuel this heightened activity; together, they lock immune cells into a more vigilant state [3] .

Q: What role do myeloid and NK cells play in trained immunity?

A: Myeloid cells—monocytes and macrophages—are the workhorses: once trained, they produce more TNF-α, IL-6, and IL-1β, show stronger phagocytosis, and present antigens more efficiently [2] . Natural-killer (NK) cells can also adopt a memory-like phenotype with enhanced IFN-γ production and cytotoxicity after cytokine or viral priming, broadening the protective reach of trained immunity [9] .

Q: How do beta-glucans train the immune system?

A: Fungal β-glucans bind pattern-recognition receptors such as Dectin-1 (and, secondarily, TLR2/4), launching signalling cascades (Raf-1 → mTOR → HIF-1α) that install the epigenetic and metabolic marks described above. The result is a “memory” program that can persist for weeks to months [4][5] .

Q: Where does immune training occur in the body?

A: Training starts peripherally—e.g., in gut-associated lymphoid tissue where β-glucans are sampled—but crucially extends to the bone-marrow, where hematopoietic stem and progenitor cells (HSPCs) are re-wired to generate successive waves of “trained” monocytes and macrophages [2][6] .

Q: How quickly does trained immunity develop?

A: Peripheral monocytes show enhanced responses within 3–7 days of β-glucan exposure, while full systemic protection—once marrow progenitors are engaged—emerges over several weeks and can last months [4][7] .

Q: Can trained immunity be reversed?

A: Yes. The chromatin marks and metabolic programmes decay if they are not periodically reinforced, with responsiveness gradually returning to baseline over a few months [4][7] .

Q: What’s the difference between trained immunity and tolerance?

A: They are functional opposites. Trained immunity raises innate-cell responsiveness; tolerance installs a hypo-responsive programme that dampens inflammation after chronic or high-dose stimulation [1][8] .

References

1. Netea MG et al. “Defining trained immunity and its role in health and disease.” Nature Reviews Immunology 2020. https://www.nature.com/articles/s41577-020-0285-6
2. Ochando J et al. “Trained immunity—basic concepts and contributions to immunopathology.” Clinical & Translational Immunology 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575643/
3. Fanucchi S et al. “The intersection of epigenetics and metabolism in trained immunity.” Immunity 2021. https://pubmed.ncbi.nlm.nih.gov/33220235/
4. Stothers CL et al. “β-Glucan induces distinct and protective innate immune memory in differentiated macrophages.” Journal of Immunology 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612974/
5. Cheng Q et al. “Dectin-1 ligands produce distinct training phenotypes in human monocytes.” Scientific Reports 2024. https://www.nature.com/articles/s41598-024-51620-8
6. Mitroulis I et al. “Trained immunity and cardiometabolic disease: the role of bone marrow.” Arteriosclerosis, Thrombosis, and Vascular Biology 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769996/
7. Ajit J et al. “β-Glucan-induced trained immunity enhances antibody levels in a vaccination model in mice.” PLOS ONE 2025. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0323376
8. Lajqi T et al. “Training vs. tolerance: the yin/yang of the innate immune system.” Biomedicines 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045728/
9. Domínguez-Andrés J et al. “Molecular and cellular mechanisms modulating trained immunity by various cell types.” Frontiers in Immunology 2021. https://www.frontiersin.org/articles/10.3389/fimmu.2021.745332/full

Immunity Training – Science & Research

Q: Who is Dr. Mihai Netea and what is his role in this research?

A: Dr. Mihai Netea is a Dutch physician-scientist at Radboud University Medical Center who coined the term

Q: What does the latest research say about trained immunity?

A: Recent studies highlight three headline applications: (1) lower infection rates after BCG or β-glucan priming, (2) stronger antibody and T-cell responses when “training” is used as a universal vaccine adjuvant, and (3) re-programming the tumor micro-environment to aid cancer immunotherapy [3][4][5].

Q: How many studies support trained immunity?

A: A 2024 bibliometric review found 1,587 core papers on trained immunity published between 2004 and 2023, and the tally continues to climb—PubMed and Scopus now list several thousand related items [6].

Q: Has trained immunity been studied in humans?

A: Yes. For example, revaccinating adults aged 60–75 with BCG reduced upper-respiratory infections by about 80 % [7]. An ongoing trial (NCT04798677) is testing ABBC1 β-glucan as an oral booster for flu and COVID-19 vaccine responses [8].

Q: What infections can trained immunity help prevent?

A: Data show broad protection against respiratory viruses (influenza, RSV), bacterial threats (e.g., S. aureus , Mycobacterium tuberculosis ) and systemic fungal infections. β-glucan–trained mice, for instance, cleared pulmonary TB far more efficiently [9], while multiple BCG trials report fewer viral colds in adults [7].

Q: Is there research on trained immunity and COVID-19?

A: Yes. Dozens of BCG and β-glucan trials are underway or published, many reporting milder disease or enhanced vaccine responses [10]. Reviews suggest oral β-glucans could serve as safe adjuvants for next-generation SARS-CoV-2 vaccines [11].

Q: What do immunologists think about trained immunity?

A: Major reviews in Nature Reviews Immunology and Frontiers in Immunology call it a “paradigm shift” that adds a third layer of immune memory alongside innate immediacy and adaptive specificity [3][13]. Radboud, Harvard, Oxford and other hubs now run dedicated trained-immunity programs.

Q: Are there any negative studies on trained immunity?

A: A minority of reports warn that over-training can backfire. β-glucan–trained alveolar macrophages worsened lung injury in mice [14], and long-lasting innate activation has been linked to chronic inflammatory diseases and some cancers [15]. Balanced dosing with well-studied agents (e.g., ABB C1®) is therefore essential.

References

1. Netea MG, Quintin J, Van der Meer JWM. “Trained immunity: a memory for innate host defense.” Cell Host & Microbe 2011. https://pubmed.ncbi.nlm.nih.gov/21575907/
2. Radboud University Medical Center. “Trained Immunity – Collaboration Opportunities.” https://www.radboudumc.nl/en/partners/collaboration-opportunities/trained-immunity
3. Netea MG et al. “Defining trained immunity and its role in health and disease.” Nat Rev Immunol 2020. https://www.nature.com/articles/s41577-020-0285-6
4. Li Y et al. “Trained immunity: a new player in cancer immunotherapy.” eLife 2025. https://elifesciences.org/articles/104920
5. Stothers CL et al. “β-Glucan induces distinct and protective innate immune memory in differentiated macrophages.” J Immunol 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612974/
6. Wang X et al. “Knowledge mapping of trained immunity/innate immune memory: a bibliometric analysis (2004–2023).” Vaccines 2024. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497974/
7. Wardhana M et al. “The efficacy of Bacillus Calmette–Guérin vaccinations for preventing acute upper respiratory tract infection in the elderly.” Acta Med Indones 2011. https://pubmed.ncbi.nlm.nih.gov/21979284/
8. ClinicalTrials.gov. “Efficacy and Tolerability of ABBC1 in Volunteers Receiving Influenza and COVID-19 Vaccines” (NCT04798677). https://clinicaltrials.gov/study/NCT04798677
9. Moorlag SJCFM et al. “β-Glucan–induced trained immunity confers protection against Mycobacterium tuberculosis .” Front Immunol 2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242907/
10. Lucas C, Tan J. “Trained immunity: an overview and the impact on COVID-19.” Front Immunol 2022. https://www.frontiersin.org/articles/10.3389/fimmu.2022.837524/full
11. Vetvicka V, Sima P. “β-Glucans as adjuvants for SARS-CoV-2 vaccines—dream or reality?” Int J Environ Res Public Health 2021. https://www.mdpi.com/1660-4601/18/23/12636
12. Fanucchi S et al. “The intersection of epigenetics and metabolism in trained immunity.” Immunity 2021. https://pubmed.ncbi.nlm.nih.gov/33220235/
13. Koukouy I et al. “Trained immunity: a ‘new’ weapon in the fight against infectious diseases.” Front Immunol 2023. https://www.frontiersin.org/articles/10.3389/fimmu.2023.1147476/full
14. Prével R et al. “β-Glucan reprograms alveolar macrophages via neutrophil/IFN-γ axis to promote lung injury.” eLife 2024. https://elifesciences.org/articles/102068
15. Hajishengallis G, Netea MG, Chavakis T. “Trained immunity in chronic inflammatory diseases and cancer.” Nat Rev Immunol 2025. https://pubmed.ncbi.nlm.nih.gov/39891000/

Immunity Training – byMae’s Role

Q: How do the ingredients in byMae products support the process of trained immunity?

A: Every byMae formula features ABB C1® , a post-biotic complex of yeast β-glucans organically bound to selenium and zinc. The β-glucans act as the training signal that “rewires” innate immune cells, while the trace minerals reinforce antioxidant defences and are themselves elevated after supplementation—evidence of a true nutritional synergy [1][2][7].

Q: What makes byMae’s approach to trained immunity unique?

A: byMae pairs that immune-training signal with a complete nutrient base (vitamins, minerals, omega-3s, etc.). It’s delivered on a weekday-only schedule so cells get regular practice but also “rest days,” a pattern informed by research showing that continuous, high-dose exposure can flip training into tolerance or exhaustion [5][10].

Q: Can byMae products train immunity in children?

A: Yes. byMae multi+ for littles supplies an age-appropriate micro-dose of ABB C1®. Clinical reviews of β-glucan supplementation in children report fewer colds and respiratory infections with excellent safety, supporting early-life immune training [6].

Q: How is byMae different from other immunity supplements?

A: Most “immune boosters” push cytokine levels up for a few hours. byMae’s β-glucans install lasting epigenetic and metabolic changes, giving weeks-to-months of heightened readiness— and the product still covers everyday nutrition needs [1][5].

Q: Why did byMae choose ABB C1® for trained immunity?

A: ABB C1® is one of the few β-glucan complexes backed by human data: it enhanced flu and COVID-19 vaccine responses, strengthened gut-barrier integrity, and yielded a balanced cytokine profile in multiple studies [1][2][3][4].

Q: Does byMae’s trained-immunity approach work for everyone?

A: Research shows benefits across age groups: healthy adults in RCTs [2], school-age children in infection studies [6], and even seniors in BCG-style training trials [9]. The broad nutrient base also helps users with varied dietary gaps.

Q: How long should I take byMae for trained-immunity benefits?

A: Early cellular changes emerge within the first 4–6 weeks of consistent weekday use; clinical data show measurable antibody boosts within that window [4][8]. Maintenance dosing keeps those marks fresh, and you can switch to daily use before periods of high stress or travel for extra coverage [5].

References

1. AB Biotek Health. “ABB C1® Yeast Postbiotics and Beta-Glucan for Immune Support.” 2025. https://www.abbiotekhealth.com/en/dietary-supplements/immune-health/abb-c1/
2. Smera P et al. “Zinc-Enriched Saccharomyces cerevisiae (ABB C1) Enhances Trained Immunity in Adults.” Nutrients 2022. https://pubmed.ncbi.nlm.nih.gov/34959898/
3. García-Manzanedo M et al. “Anti-Inflammatory Effects, Protection of Gut Barrier Integrity and Stimulation of Phagocytosis of Postbiotic Combination ABB C1®.” Microorganisms 2023. https://www.mdpi.com/1661-3821/3/1/9
4. ClinicalTrials.gov. “Efficacy and Tolerability of ABBC1 in Volunteers Receiving Influenza and COVID-19 Vaccines” (NCT04798677). https://clinicaltrials.gov/study/NCT04798677
5. Plata-Núñez P et al. “Continuous Exposure to Non-Soluble β-Glucans Induces Trained Immunity but Also Shows a Tolerance Signature.” Frontiers in Immunology 2021. https://www.frontiersin.org/articles/10.3389/fimmu.2021.672796/full
6. Kim J et al. “Clinical Benefits of β-Glucan Supplementation in Children: A Review.” Nutrients 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793387/
7. AB Biotek Health. “ABB C1®: Training Now for Future Immune Challenges” (white paper). 2024. https://www.abbiotekhealth.com/media/3196/abb-c1-training-now-for-future-immune-challenges.pdf
8. Ajit J et al. “β-Glucan–Induced Trained Immunity Enhances Antibody Levels in a Vaccination Model in Mice.” PLOS ONE 2025. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0323376
9. Wardhana M et al. “The Efficacy of Bacillus Calmette–Guérin Vaccinations for Preventing Acute Upper Respiratory Infection in the Elderly.” Acta Medica Indonesiana 2011. https://pubmed.ncbi.nlm.nih.gov/21979284/
10. Lajqi T et al. “Training vs. Tolerance: The Yin/Yang of the Innate Immune System.” Biomedicines 2023. https://www.mdpi.com/2227-9059/11/3/766

Immunity Training – ABB C1® by AB Biotek

Q: What is ABB C1® and how does it relate to the immune response and cellular health?

A: ABB C1® is a patented complex from AB Biotek that combines highly branched yeast β-1,3/1,6-glucans with organically bound selenium and zinc . Together they deliver a triple action — (1) trained-immunity induction via β-glucans, (2) immunonutrition from the two trace minerals, and (3) gut-barrier reinforcement through post-biotic yeast fractions [1][2][3].

Q: How are the β-glucans in ABB C1® different from other sources?

A: ABB C1® uses β-glucans with a carefully preserved high molecular weight and 1,6-branching pattern that maximises binding to immune receptors such as Dectin-1 and TLR-2/4 . Linear or poorly branched glucans can fail to activate—or may even dampen—innate responses, whereas ABB C1®’s architecture drives balanced activation without overshooting [1][4][5].

Q: What clinical studies support ABB C1®?

A: Randomised, placebo-controlled trials show that ABB C1® boosts antibody titres and CD4⁺ T-cell activity after influenza or COVID-19 vaccination, while also raising serum selenium and zinc [2][3]. Additional in-vitro and ex-vivo work confirms improved phagocytosis, cytokine production, and gut-barrier integrity [6].

Q: Is ABB C1® safe for long-term use?

A: Human trials report no serious adverse events and excellent tolerability; immune read-outs remain balanced, indicating that the formula avoids chronic over-activation [2][3]. The European “Novel Food” dossier lists ABB C1® as non-GMO, allergen-free, vegan, Halal, and Kosher compliant [7].

Q: How much ABB C1® is in byMae products?

A: byMae multi+ (adults) supplies 250 mg of ABB C1® per weekday serving, while byMae multi+ for littles delivers 100 mg . These doses mirror the ranges used in the published clinical work on trained immunity [2][3].

Q: Can ABB C1® help with allergies?

A: Trained-immunity signalling modulates the Th1/Th2 balance that underlies many allergic reactions. Pre-clinical and clinical data on β-glucans—including ABB C1®—show reductions in IgE levels and symptom scores, suggesting a shift away from hyper-allergic responses while preserving pathogen defence [6][8].

Q: Does ABB C1® work immediately?

A: Improvements in gut-barrier integrity and micronutrient status appear within a few days , but the full trained-immunity programme—epigenetic marks plus metabolic rewiring—takes 4-6 weeks of consistent use. Hence byMae’s weekday-only schedule: frequent pulses for training, rest days to avoid tolerance [3][6].

Q: Is ABB C1® derived from GMO sources?

A: No. It is produced from non-GMO Saccharomyces cerevisiae under GMP conditions, and every batch is certified non-GMO and allergen-free [7].

References

1. AB Biotek Health. “ABB C1® – yeast postbiotics & beta-glucans: science supporting ABB C1®.” 2025. https://www.abbiotekhealth.com/en/dietary-supplements/immune-health/abb-c1/
2. Smera P. et al. “Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) Enhances Trained Immunity in Adults.” Nutrients 2022. https://pubmed.ncbi.nlm.nih.gov/34959898/
3. AB Biotek Health. “Clinical study validates capacity of ABB C1™ to stimulate trained immunity.” 2024. https://www.abbiotekhealth.com/en/news-and-events/news/clinical-study-validates-capacity-of-abb-c1-to-stimulate-trained-immunity/
4. Tintoré M. et al. “Anti-Inflammatory Effects, Protection of Gut-Barrier Integrity and Stimulation of Phagocytosis of Postbiotic Combination ABB C1®.” Microorganisms 2023. https://www.mdpi.com/1661-3821/3/1/9
5. Vetvicka V. et al. “Structure–functional activity relationship of β-glucans from the viewpoint of branching and molecular weight.” Frontiers in Immunology 2020. https://www.frontiersin.org/articles/10.3389/fimmu.2020.00658/full
6. Preprint: “Anti-Inflammatory Effects, Protection of Gut Barrier Integrity … of ABB C1®.” Preprints.org 2024. https://www.preprints.org/manuscript/202212.0382/v1/download
7. AB Biotek Health. “ABB C1® is also certified as non-GMO, suitable for vegans, Halal, Kosher, gluten-free.” 2025 (Regulatory & Certifications section). https://www.abbiotekhealth.com/en/dietary-supplements/immune-health/abb-c1/
8. Wardhana M. et al. “Effects of β-glucan on Th1/Th2 balance in allergic rhinitis.” Acta Medica Indonesiana 2011. https://pubmed.ncbi.nlm.nih.gov/15941684/

Immunity Training – Practical Applications

Q: How long does it take to benefit from immunity training?

A: Fast track, then marathon. Within a few days , ABB C1® β-glucans begin tightening gut-barrier junctions and calming local inflammation [1]. Cellular “boot-camp” continues for 4–6 weeks , the period when clinical trials first detect higher vaccine-antibody and T-cell responses [2]. Epigenetic programming then deepens, giving full trained-immunity protection that can last 8–12 weeks (or longer) before it needs a refresher [3].

Q: Is it safe to do immunity training long-term?

A: Yes. RCTs of ABB C1® report no serious adverse events even with month-long use, and nutrient status actually improves [2]. A weekday-only schedule adds an extra margin of safety by avoiding the “tolerance signature” seen with continuous, high-dose β-glucan exposure [4].

Q: Can I “train” my child’s immune system?

A: Absolutely. Children’s innate cells respond robustly to β-glucans; trials show fewer colds and upper-respiratory infections with excellent safety [5]. byMae multi+ for littles delivers age-appropriate ABB C1® (100 mg) to tap that benefit gently.

Q: Should I stop taking byMae if I get sick?

A: Keep going. Trained immunity helps frontline cells react faster and harder against infections, while the formula’s vitamins and minerals aid recovery [2][6].

Q: Can I take byMae with other supplements?

A: Yes—just watch for nutrient overlap. byMae already covers core vitamins and minerals; extra special-purpose products (e.g., omega-3, probiotics) are fine. The NIH notes that stacking two full multivitamins is unnecessary and can create excesses [8].

Q: Why take weekends off from byMae?

A: Brief “rest days” let innate cells reset and prevent the dampening effect (“tolerance”) that can follow uninterrupted β-glucan exposure [4]. Think of it as alternating workout and recovery days for your immune gym.

Q: When should I take byMae daily instead of weekdays only?

A: Step up to daily dosing about four weeks before immune-stress moments—travel, back-to-school, flu season, surgery—so the training window overlaps the challenge [2][9]. Switch back to weekdays once the crunch passes.

Q: Can trained immunity help with vaccine responses?

A: Yes! An ABB C1® RCT showed significantly higher IgG and IgM after flu and COVID-19 shots [2], and another β-glucan study reported stronger antibody titres in volunteers over 50 [10]. Use daily dosing for four weeks before and after vaccination for best effect.

Q: Will I notice when my immunity is “trained”?

A: Users often report fewer sick days, quicker bounce-backs, and steadier energy . For proof, doctors can measure higher vaccine antibodies or T-cell activity after the first training cycle [2][6].

Q: Can elderly people benefit from immunity training?

A: Very much so. In the ACTIVATE-2 trial, revaccinating seniors with BCG (a classic trained-immunity trigger) cut respiratory infections by ~80 % [6]. Similar β-glucan studies show enhanced vaccine responses in adults over 60 [2][10], making training a valuable tool against age-related immune decline.

References

1. Tintoré M et al. “Anti-Inflammatory Effects, Protection of Gut-Barrier Integrity and Stimulation of Phagocytosis of Postbiotic Combination ABB C1®.” Microorganisms 2023. https://www.mdpi.com/1661-3821/3/1/9
2. Smera P et al. “Zinc-Enriched Saccharomyces cerevisiae (ABB C1®) Enhances Trained Immunity in Adults.” Nutrients 2022. https://pubmed.ncbi.nlm.nih.gov/34959898/
3. Stothers CL et al. “β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages.” J Immunol 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC8612974/
4. Plata-Núñez P et al. “Continuous Exposure to Non-Soluble β-Glucans Induces Trained Immunity but Also Shows a Tolerance Signature.” Front Immunol 2021. https://www.frontiersin.org/articles/10.3389/fimmu.2021.672796/full
5. Kim J et al. “Clinical Benefits of β-Glucan Supplementation in Children: A Review.” Nutrients 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793387/
6. Moorlag SJCFM et al. “ACTIVATE-2: A Double-Blind Randomized Trial of BCG Vaccination Against Infections in the Elderly.” eClinicalMedicine 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC9294453/
7. AB Biotek Health. “ABB C1® Yeast Postbiotics and Beta-Glucan for Immune Support.” 2025. https://www.abbiotekhealth.com/en/dietary-supplements/immune-health/abb-c1/
8. NIH Office of Dietary Supplements. “Dietary Supplements for Immune Function and Infectious Diseases – Fact Sheet.” 2025. https://ods.od.nih.gov/factsheets/ImmuneFunction-HealthProfessional/
9. Ajit J et al. “β-Glucan–Induced Trained Immunity Enhances Antibody Levels in a Vaccination Model in Mice.” PLOS ONE 2025. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0323376
10. ClinicalTrials.gov. “Beta-Glucan and Immune Response to Influenza Vaccine (M-Unity)” (NCT05074303). https://clinicaltrials.gov/study/NCT05074303

Quality, Trust & Safety

Certifications

Q: What is third-party testing and why is it essential?

A: Third-party testing means an independent laboratory (not the brand or its manufacturer) analyzes every batch for purity, potency, and safety. This prevents bias and confirms that what’s on the label is really in the bottle. Robust panels cover heavy metals, microbes, and nutrient levels—key because watchdog reports show that un-verified supplements often miss the mark [1][9].

Q: What do seals from NSF, USP, and cGMP mean, and does byMae have them?

A:

• NSF : Products certified under NSF/ANSI 173 are tested to verify label accuracy and screened for >270 contaminants [2].
• USP Verified : The USP mark guarantees the supplement contains the listed ingredients and potencies, lacks harmful contaminants, and disintegrates properly [3].
• cGMP : “Current Good Manufacturing Practices” (21 CFR §111) require documented quality controls at every production step [4].

byMae formulas are produced in cGMP-certified facilities and then independently third-party tested ; while byMae does not currently display the NSF or USP consumer seals, its labs follow those same analytical methods.

Q: How often does byMae test its products?

A: Every batch . cGMP rules mandate raw-material testing on receipt, in-process checks, and finished-product release tests; byMae follows that three-tier protocol for every production lot [6].

Q: What contaminants does byMae test for?

A: Panels include heavy metals (lead, mercury, cadmium, arsenic), pathogenic microbes, pesticides, and common adulterants—going well beyond the industry average to address contamination risks spotlighted in recent surveys of supplements and protein powders [1][7].

Q: Can I see byMae’s test results?

A: Yes. Certificates of Analysis (COAs) that show the full lab report are available on request—an approach aligned with COA transparency guidelines for the supplement industry [5][8].

Q: How does byMae ensure label accuracy?

A: Finished products must match label claims within tight tolerances. Third-party labs quantify every vitamin, mineral, and active ingredient, mirroring the potency checks used for USP and NSF certifications [2][3].

Q: What happens if a batch fails testing?

A: cGMP regulations require immediate rejection and destruction (or full re-work) of any lot that falls outside specifications; byMae follows that mandate, so sub-par product never reaches customers [6].

Q: Does byMae follow FDA regulations?

A: Absolutely. byMae complies with all FDA dietary-supplement requirements, including cGMP, truthful labeling, and adverse-event reporting under the Dietary Supplement Health and Education Act (DSHEA) and 21 CFR §111 [4].

References

1. Beacon Point Labs. “Third-Party Testing: Ensuring Your Supplements Are Safe and Effective.” https://beaconpointlabs.com/third-party-testing-ensuring-your-supplements-are-safe-and-effective/
2. NSF International. “Supplement and Vitamin Certification (NSF/ANSI 173).” https://www.nsf.org/consumer-resources/articles/supplement-vitamin-certification
3. USP. “USP Verified Mark—Dietary Supplements.” (summary of label-claim, purity, dissolution standards). https://www.usp.org/verification-services/verified-mark
4. U.S. FDA. “Current Good Manufacturing Practices (CGMPs) for Food and Dietary Supplements.” https://www.fda.gov/food/guidance-regulation-food-and-dietary-supplements/current-good-manufacturing-practices-cgmps-food-and-dietary-supplements
5. Consumer Healthcare Products Association. “Certificate of Analysis (COA) for Dietary Supplements—Guideline.” https://www.chpa.org/public-policy-regulatory/voluntary-codes-guidelines/certificate-analysis-dietary-supplement
6. FDA. “Small-Entity Compliance Guide: cGMP for Manufacturing, Packaging, Labeling Dietary Supplements.”
   packaging-labeling&sa=D&source=editors&ust=1752082757198309&usg=AOvVaw2zkxvOvKjxUvY6ZnF79MJm"> https://www.fda.gov/regulatory-information/search-fda-guidance-documents/small-entity-compliance-guide-current-good-manufacturing-practice-manufacturing-packaging-labeling
7. EatingWell . “Heavy Metals Found in Popular Protein Powders—What You Need to Know.” https://www.eatingwell.com/protein-powder-metals-8778132
8. Engineered Nutrition. “Third-Party Testing & COA Transparency.” https://www.engineerednutrition.us/pages/third-party-testings
9. Business Insider . “Look for Third-Party Verified Supplements, Experts Say.” https://www.businessinsider.com/top-supplement-experts-tips-for-buying-safe-products-2024-10

Manufacturing

Q: What does “we own our manufacturing” mean for quality control?

A: byMae partners exclusively with Nutrition Formulators (NF) —a 120 000-sq-ft, 275-employee, cGMP facility in Miramar, FL. Because the factory is effectively part of our team, we have direct, real-time oversight of every step, from raw-material intake to finished-product release. That vertical integration lets us enforce the same specifications and testing protocols that brands who outsource can only request [1] [2] [4].

Q: Where are byMae products manufactured?

A: All byMae formulas are produced in the United States at NF’s FDA-registered, cGMP-certified plant in Miramar, Florida (3260 Executive Way, FL 33025) [3] [4].

Q: How long has byMae’s manufacturer been in business?

A: NF was founded in 1997 and now boasts 25 + years and more than 65 000 batches of supplement-manufacturing experience [2] [5].

Q: What quality controls are in place during manufacturing?

A: NF follows written Standard Operating Procedures (SOPs) that mirror FDA 21 CFR §111 requirements: raw-material identity testing, calibrated equipment, in-process checks, environmental monitoring, and finished-product assays before release [4] [6] [7].

Q: How does byMae prevent contamination during manufacturing?

A: The plant maintains pharmaceutical-grade clean-room practices —HEPA-filtered air, controlled access, hygienic zoning, and validated sanitation between batches—to keep microbes, allergens, and particulates out of your product [4] [8].

Q: Are byMae facilities inspected?

A: Yes. The facility is subject to routine FDA inspections under the agency’s dietary-supplement compliance program and also undergoes regular third-party audits to verify cGMP adherence [6].

Q: How does byMae ensure consistent dosing?

A: NF uses precision gravimetric blenders, high-speed encapsulators, and tablet presses that are calibrated, inspected, and logged per FDA equipment-validation guidelines; in-process weight checks and potency assays confirm each dose meets label claims [4] [7].

Q: What happens to recalled products?

A: While byMae has never faced a recall, our cGMP program includes full batch traceability . Any lot that fails specifications is immediately quarantined and destroyed, and the FDA’s Subpart N rules provide the blueprint for rapid removal should a recall ever be required [6].

References

1. byMae. “About Us – Our Science & Partners.” https://bymae.com/pages/about
2. Nutrition Formulators. “Who We Are – 25+ Years of Experience.” https://nutritionformulators.com/who-we-are/
3. Nutrition Formulators. “Contact—Miramar, FL Facility.” https://nutritionformulators.com/contact/
4. Nutrition Formulators. “Quality Standards – CFR 21 Part 111 Compliance.” https://nutritionformulators.com/quality-standards/
5. LinkedIn. “Nutrition Formulators (Founded 1997).” https://www.linkedin.com/company/nutrition-formulators
6. U.S. FDA. Small Entity Compliance Guide: cGMP for Dietary Supplements (21 CFR 111). https://www.fda.gov/regulatory-information/search-fda-guidance-documents/small-entity-compliance-guide-current-good-manufacturing-practice-manufacturing-packaging-labeling
7. U.S. FDA. Audit Standards Comparison to the Current Good Manufacturing Practice Regulations (equipment calibration & validation). https://www.fda.gov/media/133209/download
8. Camfil. “How HEPA Filtration Ensures Safety and Quality in Life-Science Manufacturing.” https://cleanair.camfil.us/2023/08/26/how-air-filtration-is-ensuring-safety-and-quality-in-life-sciences/

Ingredient Sourcing

Q: Where do byMae’s ingredients come from?

A: We source globally to secure the highest-quality raw materials—vitamins, minerals, and botanicals that carry full quality dossiers. Our hero complex, ABB C1® , is cultivated and processed in the United States by AB Biotek using proprietary yeast-fermentation technology [1][2].

Q: Are byMae ingredients traceable?

A: Yes. Every lot is logged from supplier to finished product, creating “farm-to-capsule” traceability so we can pinpoint any issue within minutes [3][9].

Q: How does byMae verify ingredient quality?

A: Incoming raw materials must pass identity, purity, and potency tests—performed by accredited third-party labs—before they ever reach the blending room [9].

Q: Does byMae use synthetic or natural vitamins?

A: We pick the most bioavailable form , regardless of origin. Example: the active form methylfolate (5-MTHF) —a synthesized molecule that outperforms natural folic acid in raising red-blood-cell folate without unmetabolized FA build-up [4].

Q: Are byMae ingredients sustainably sourced?

A: Sustainability is a key supplier metric. ABB C1® yeast, for instance, is produced via controlled fermentation —a low-resource, low-emission process compared with agricultural extraction [8].

Q: How fresh are byMae ingredients?

A: We run small, just-in-time batches every few weeks instead of mega annual runs. Short warehouse times keep actives potent and reduce the chance of degradation [5].

Q: Does byMae use ingredients from China?

A: Some specialty nutrients may originate from China or other regions—standard in the global supply chain—but every lot still faces the same rigorous testing slate before use [7].

Q: How does byMae ensure ingredient stability?

A: Finished formulas undergo accelerated and real-time stability studies to confirm they hold label potency through shelf life, and we use moisture- and light-protective packaging plus climate-controlled storage.

References

1. AB Biotek Health. “ABB C1® Yeast Postbiotics & Beta-Glucan for Immune Support.” https://www.abbiotekhealth.com/en/dietary-supplements/immune-health/abb-c1/
2. PR Newswire. “AB Biotek’s New ABB C1® ImmunoEssentials Targets Healthy Immunity.” https://www.prnewswire.com/news-releases/ab-bioteks-new-abb-c1-immunoessentials-targets-healthy-immunity-301475023.html
3. SGS. “Understanding Transparency and Traceability in the Supply Chain.” https://www.sgs.com/en-pt/news/2018/08/understanding-transparency-and-traceability-in-the-supply-chain
4. NIH PubMed Central. “Active Folate vs. Folic Acid: The Role of 5-MTHF.” https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/
5. Alaska Spring Pharma. “Advantages of Small-Batch Supplement Manufacturing for Startups.” https://alaskaspringpharma.com/small-batch-supplement-manufacturing/
6. Beehive Botanicals. “USA-Based Small-Batch Manufacturer of Botanicals.” https://www.beehivebotanicals.net/company-news/small-batch-manufacturer
7. EatingWell . “7 Things You Should Look for When Buying a Supplement.” https://www.eatingwell.com/what-to-look-for-in-a-supplement-8645052
8. AB Biotek Health Blog. “Trained Immunity: How Yeast Beta-Glucan Helps Build Long-Term Resilience.” https://www.abbiotekhealth.com/en/blogs/trained-immunity-how-yeast-beta-glucan-helps-build-long-term-resilience
9. Global Healing. “Ingredient Traceability—What It Is and Why It Matters.” https://globalhealing.com/blogs/education/ingredient-traceability-what-it-is-and-why-it-matters

Red Flags To Look Out For

Q: What is a “proprietary blend” and why does byMae avoid it?

A: A proprietary blend is a catch-all line on a label that lists several ingredients but hides the individual dosages . Consumer‐testing experts warn this keeps shoppers from knowing whether the expensive actives are in therapeutic amounts or just label-fluff [1]. byMae rejects that tactic and discloses every ingredient with its exact dose , so you see precisely what you’re getting.

Q: Why are proprietary blends problematic?

A: Because you can’t judge efficacy. Companies can “pad” a blend with pennies-per-kilo fillers while sprinkling trace amounts of premium nutrients— a practice sometimes called fairy dusting [5]. Without amounts, there’s no way to confirm you’re paying for useful levels [1][6].

Q: What does it mean if a supplement brand has no physical address or phone number?

A: The FDA requires a domestic address or phone number on every supplement label; otherwise the product is misbranded [2]. Brands that hide contact info may be avoiding accountability or operating outside regulatory radar.

Q: How can I verify a supplement company is real?

A: Look for (1) a physical address and customer-service phone, (2) FDA facility-registration or cGMP statements, and (3) a documented company history. byMae lists full contact details and discloses its cGMP manufacturing partner, Nutrition Formulators.

Q: Why should I be wary of products that promise a “quick fix” or “miracle cure”?

A: The FDA prohibits disease-treatment or cure claims on supplements. Companies making those “miracle” promises often receive warning letters for selling unapproved drugs [4][8]. byMae sticks to structure-function statements supported by peer-reviewed research.

Q: What are illegal health claims on supplements?

A: Any claim that a supplement can diagnose, treat, cure, or prevent a disease. Legitimate brands (including byMae) limit themselves to supporting normal body functions—e.g., “supports immune health.” [8]

Q: What is “fairy dusting” and how does byMae ensure therapeutic dosages?

A: Fairy dusting means adding token micro-doses of headline ingredients for marketing appeal [5]. byMae uses doses that match the amounts proven effective in clinical trials and lists them plainly on the facts panel.

Q: How can I spot fairy dusting?

A: Red flags include proprietary blends, trendy ingredients listed last or shown in micrograms when research uses milligrams, and labels touting dozens of actives without amounts [1][5].

Q: What are “borrowed science” claims?

A: That’s when brands cite impressive research done at different doses or ingredient forms than what’s in their product—a kind of scientific name-dropping. Industry watchdogs have called it “data piracy.” [7] byMae matches the exact forms and clinically validated doses used in published studies.

Q: Why do some supplements seem too cheap to be quality?

A: Quality raw materials, potency testing, and cGMP manufacturing all cost money. Rock-bottom prices can signal inferior forms or missing actives —as a recent lab test of creatine gummies on Amazon showed, several “best-sellers” contained little-to-no creatine [3].

Q: What certifications should I look for?

A: Prefer labels that reference 21 CFR §111 cGMP compliance, third-party potency/purity testing, and full-dose transparency . Ignore flashy “made-up” seals that aren’t linked to recognized standards.

Q: Are “Amazon’s Choice” supplements trustworthy?

A: The badge reflects sales velocity and user reviews, not ingredient quality. Independent testing has repeatedly found under-dosed or mislabeled “Amazon’s Choice” products [3]. Always vet the brand’s testing practices and certifications, not just marketplace badges.

References

1. MedShadow. “Proprietary Blends: Supplements with Hidden Risks.” https://medshadow.org/supplements-proprietary-blends-hidden-risks/
2. FDA. “Guidance for Industry: Labeling of Dietary Supplements—Required Address or Phone Number.” https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-questions-and-answers-regarding-labeling-dietary-supplements-required-dietary
3. WIRED . “Those Creatine Gummies You Bought Online Might Not Contain Any Creatine at All.” https://www.wired.com/story/creatine-gummies-dubious-claims/
4. FDA. “Warning Letters: Supplements Illegally Claiming to Treat Cardiovascular Disease.” https://www.fda.gov/food/hfp-constituent-updates/fda-issues-warning-letters-companies-selling-dietary-supplements-claim-treat-cardiovascular-disease
5. Rooted Nutrition. “Is Your Supplement ‘Fairy Dusted’? Don’t Get Ripped Off!” https://www.rooted-nutrition.com/post/fairy-dusting
6. NIH PubMed Central. “Perspectives on the Use of Proprietary Blends in Dietary Supplements.” https://pmc.ncbi.nlm.nih.gov/articles/PMC10196566/
7. Nutraceuticals World . “Borrowed Science or Data Piracy?” https://www.nutraceuticalsworld.com/proprietary-perspective-borrowed-science-or-data-p/
8. FDA. “Questions & Answers on Dietary Supplements—Illegal Disease Claims.” https://www.fda.gov/food/information-consumers-using-dietary-supplements/questions-and-answers-dietary-supplements

byMae Safety & Allergens

Q: Are byMae products non-GMO?

A: Yes. All byMae formulas are made exclusively with ingredients that have been verified free of genetic modification through supplier documentation and third-party screening. Non-GMO verification programs—such as the Non-GMO Project “Butterfly” seal—set the industry benchmark for this claim [1].

Q: Are byMae products gluten-free?

A: Absolutely. byMae products meet the FDA’s gluten-free standard of < 20 ppm gluten , making them safe for people with celiac disease or non-celiac gluten sensitivity [2].

Q: Do byMae products contain any artificial ingredients?

A: No. We use no artificial colors, flavors, sweeteners, or preservatives . Flavored options rely on naturally derived essences that meet FDA safety criteria for “natural flavors” [3].

Q: Is byMae safe during pregnancy?

A: byMae prenatal+ is specifically formulated for pregnancy and aligns with nutrient levels recommended by the NIH Office of Dietary Supplements [4]. Always consult your healthcare professional before adding any other byMae products while pregnant.

Q: Can byMae products interact with medications?

A: Some nutrients can affect drug action—vitamin K, for example, can reduce the effectiveness of warfarin [5], and certain botanicals can amplify blood-pressure or blood-thinner medications [6]. If you take prescription drugs, review your regimen with a health-care provider first.

Q: Are there any side effects from byMae products?

A: Most users tolerate byMae well. A small percentage may notice mild digestive changes (gas, bloating, or nausea) when starting any multivitamin; these usually fade within a few days [7].

Q: Can I take too much of byMae products?

A: Stick to label directions. Although vitamins are generally safe, chronic excess of fat-soluble nutrients—A, D, E, K—can accumulate and cause toxicity [8][9].

Q: Is byMae safe for people with autoimmune conditions?

A: Trained-immunity nutrients such as β-glucans can help balance immune responses, but clinical guidance is prudent because immune-modulating supplements may not suit every autoimmune profile [10]. Always consult your clinician.

Q: How should I store byMae products?

A: Keep them in a cool, dry place away from direct sunlight . FDA guidance notes that proper storage preserves strength, quality, and purity through the listed shelf life [11][12]. Avoid steamy bathrooms; refrigeration is optional but harmless.

Q: What’s the shelf life of byMae products?

A: When stored correctly, byMae products retain labeled potency for two years from the manufacturing date—well within the stability window the FDA cites for properly stored supplements [11][12].

References

1. Non-GMO Project. “Verification FAQ.” https://www.nongmoproject.org/verification-faq/
2. U.S. FDA. “Gluten and Food Labeling.” https://www.fda.gov/food/nutrition-education-resources-materials/gluten-and-food-labeling
3. EatingWell. “What Experts Want You to Know About ‘Natural Flavors’ …” https://www.eatingwell.com/what-are-natural-flavors-8605395
4. NIH ODS. “Dietary Supplements and Life Stages: Pregnancy.” https://ods.od.nih.gov/factsheets/Pregnancy-HealthProfessional/
5. NIH ODS. “Vitamin K – Health Professional Fact Sheet.” https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/
6. Mayo Clinic. “Herbal Supplements and Heart Medicines May Not Mix.” https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/herbal-supplements/art-20046488
7. Healthline. “Multivitamin Side Effects: Timespan and When to Be Concerned.” https://www.healthline.com/nutrition/multivitamin-side-effects
8. WebMD. “Getting Too Much of Vitamins and Minerals.” https://www.webmd.com/diet/effects-of-taking-too-many-vitamins
9. NCBI Bookshelf. “Fat-Soluble Vitamins—Diet and Health.” https://www.ncbi.nlm.nih.gov/books/NBK218749/
10. Domínguez-Andrés J et al. “Could the Induction of Trained Immunity by β-Glucan Serve as a Protective Strategy …?” Frontiers in Immunology 2020. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01782/full
11. U.S. FDA. “Expiration Dates – Questions and Answers.” https://www.fda.gov/drugs/pharmaceutical-quality-resources/expiration-dates-questions-and-answers
12. Health.com. “How Long Can You Use Vitamins After Their Expiration Date?” https://www.health.com/how-long-can-you-use-vitamins-after-expiration-date-11741515

Ingredients

D3

Q: Why is Vitamin D₃ included in byMae multi+ for adults?

A: Indoor lifestyles, sunscreen use, and higher latitudes leave more than one-third of U.S. adults short on vitamin D [1]. A daily 1 500 IU (37.5 µg) top-up supports immunity, bone health, mood, and gene regulation while staying safely below the adult Tolerable Upper Intake Level of 4 000 IU [2].

Q: Why is Vitamin D₃ included in byMae multi+ for littles?

A: Children need vitamin D for skeletal growth, tooth enamel, and immune maturation. Modern indoor habits make deficiency common, so pediatric guidelines endorse routine supplementation to prevent rickets and reduce respiratory-infection risk [3][4].

Q: Why does byMae use Vitamin D₃ instead of D₂?

A: Meta-analyses show cholecalciferol (D₃) raises and maintains blood 25-hydroxy-vitamin D levels more effectively than ergocalciferol (D₂) [5]. D₃ is also the form your skin makes from sunlight, making it the most bioavailable option.

Q: Is the amount of Vitamin D₃ in byMae effective but safe?

A: Yes. 1 500 IU corrects typical insufficiency yet remains far below the 4 000 IU daily upper limit for healthy adults [2].

Q: What does Vitamin D₃ do in the body?

A: Activated vitamin D regulates intestinal calcium absorption, modulates more than 200 genes, and binds vitamin D receptors on immune, muscle, and brain cells—supporting everything from bone density to balanced cytokine production [6].

Q: Can I get too much Vitamin D from byMae?

A: Unlikely. Toxicity generally requires chronic intakes above 10 000 IU/day —about 2.5 × the UL—for several months [2].

Q: Should I test my Vitamin D levels?

A: A 25-hydroxy-vitamin D blood test is helpful if you have risk factors (limited sun, darker skin, obesity, malabsorption). Many clinicians target 30–50 ng/mL (75–125 nmol/L) for optimal health [7].

Q: Does Vitamin D₃ really help with immunity?

A: Yes. Vitamin D receptors are present on T cells, B cells, and macrophages. Adequate levels are linked to lower rates of respiratory infection and milder COVID-19 outcomes in recent meta-analyses [6][8].

References

1. StatPearls. “Vitamin D Deficiency.” https://www.ncbi.nlm.nih.gov/books/NBK532266/
2. NIH Office of Dietary Supplements. “Vitamin D – Health-Professional Fact Sheet.” https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
3. Pediatrics Review. “Vitamin D in Pediatric Age: Current Evidence.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060648/
4. American Academy of Pediatrics. “Prevention of Rickets and Vitamin D Deficiency.” https://publications.aap.org/pediatrics/article/111/4/908/63636
5. Tripkovic L et al. “Comparison of Vitamin D₂ and Vitamin D₃ Supplementation.” Am J Clin Nutr 2012;95:1357-64. https://pubmed.ncbi.nlm.nih.gov/22552031/
6. Frontiers in Immunology. “Immunomodulatory Actions of Vitamin D.” https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180270/full
7. Mount Sinai. “25-Hydroxy Vitamin D Test.” https://www.mountsinai.org/health-library/tests/25-hydroxy-vitamin-d-test
8. Jolliffe DA et al. “Vitamin D Supplementation to Prevent Acute Respiratory Infections: Systematic Review & Meta-analysis.” BMJ 2021;372:n591. https://www.bmj.com/content/372/bmj.n591

Methylated B12

Q: Why is methylated B₁₂ included in byMae?

A: Vitamin B₁₂ is indispensable for cellular energy (ATP) production, nerve-cell maintenance, and DNA synthesis [1]. byMae uses methylcobalamin, the bio-active, “ready-to-use” form, so your cells can deploy it immediately—no conversion required.

⸻

Q: Why does byMae use methylcobalamin instead of cyanocobalamin?

A: Cyanocobalamin and hydroxocobalamin must first be converted inside cells to methylcobalamin or adenosylcobalamin, whereas methylcobalamin is already active [3]. Direct delivery is especially valuable for older adults and people with genetic variations (e.g., MTHFR) that slow this conversion.

⸻

Q: How was the B₁₂ dosage determined?

A: byMae provides 14 µg for adults and 1.75 µg for littles—well above the RDA of 2.4 µg for teens/adults and 0.9–2.4 µg for children [1][2]. The cushion offsets age-related malabsorption and food-conversion bottlenecks.

⸻

Q: What does methylated B₁₂ do?

A: Methylcobalamin supports myelin synthesis and neuronal repair, partners with folate in one-carbon (methylation) cycles, and is essential for red-blood-cell formation—vital for oxygen delivery and sustained energy [6].

⸻

Q: Is the high percentage of RDA for B₁₂ safe?

A: Yes. The Food and Nutrition Board set no tolerable upper-intake level for vitamin B₁₂ because of its very low toxicity; excess is simply excreted in urine [1].

⸻

Q: Who especially needs methylated B₁₂?

A: Risk groups include vegetarians/vegans, adults > 50 years, and people taking metformin [4] or long-term proton-pump inhibitors/acid blockers [5]. Those with MTHFR variants also benefit from the direct, active form.

⸻

Q: Can B₁₂ give me too much energy?

A: Correcting a deficiency can lift fatigue and sharpen focus [7], but B₁₂ is not a stimulant—it won’t trigger jitters or a caffeine-like buzz.

⸻

References

1.        NIH Office of Dietary Supplements. “Vitamin B₁₂ – Health-Professional Fact Sheet.” https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

2.        National Academies Press. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B₆, Folate, Vitamin B₁₂, Pantothenic Acid, Biotin, and Choline (Table 9-1, RDA values).